Epley手法复位联合银杏叶提取物、甲磺酸倍他司汀片治疗耳石症眩晕患者的效果及对复发率的影响
Effect of the Epley manual reduction combined with ginkgo biloba extract and betahistine mesylate tablets in the treatment of patients with otolithiasis vertigo and its impact on the recurrence rate
李义 1高虹 2王霞 3高义恰3
作者信息
- 1. 衡水市人民医院 泌尿外科 河北 衡水 053000
- 2. 衡水市人民医院 门诊采血室 河北 衡水 053000
- 3. 衡水市人民医院 耳鼻咽喉头颈外科 河北 衡水 053000
- 折叠
摘要
目的 探究Epley手法复位联合银杏叶提取物、甲磺酸倍他司汀片治疗耳石症眩晕患者的效果及对复发率的影响.方法 将2021年3月至2022年3月衡水人民医院就诊的100例耳石症眩晕患者纳入本次前瞻性研究,按照随机数字表法将其分为对照组(n=50)和联合组(n=50).对照组患者接受银杏叶提取物片+甲磺酸倍他司汀片治疗,研究组采用Epley手法复位+银杏叶提取物片+甲磺酸倍他司汀片治疗,治疗周期为7 d.比较两组临床疗效,治疗前、治疗7 d后的前庭症状指数(VSI)评分、Berg平衡量表(BBS)评分、眩晕障碍量表(DHI)、脑动脉[左侧椎动脉(LVA)、右侧椎动脉(RVA)、基底动脉(BA)]平均血流速度,治疗1个月和6个月后的复发率及不良反应发生率.结果 联合组的总有效率为96.00％,显著优于对照组(82.00％),差异有统计学意义(P＜0.05).联合组治疗后VSI、DHI评分分别为(19.08±1.97)、(26.04±2.35)分,均显著低于对照组[(27.90±2.14)、(38.76±3.23)分],而BBS评分为(53.01±5.22)分,显著高于对照组[(32.48±4.79)分],差异均有统计学意义(P＜0.05).两组治疗后的脑动脉平均血流速度比较,差异均无统计学意义(P＜0.05).两组的不良反应发生率和治疗1个月后的复发率比较,差异均无统计学意义(P＞0.05);联合组治疗6个月后的复发率为6.00％,低于对照组(20.00％),差异有统计学意义(P＜0.05).结论 相比于单纯药物治疗,Epley手法复位+银杏叶提取物+甲磺酸倍他司汀片治疗耳石症眩晕的临床疗效更佳,可有效改善患者的前庭症状功能、平衡功能,提高脑动脉血流速度和生活质量,降低复发率,且安全性良好.
Abstract
Objective To investigate the effects of Epley manual reduction combined with ginkgo biloba extract and betahistine mesylate tablets in the treatment of patients with otolithiasis vertigo,and its impact on the recurrence rate.Methods A prospective study was conducted on 100 patients with otolithiasis vertigo admitted to Hengshui People's Hospital from March 2021 to March 2022.The patients were divided into the control group and the combination group according to the random number table method,with 50 cases in each group.The control group received treatment with ginkgo biloba extract and betahistine mesylate tablets,while the combination group received treatment with Epley manual reduction+ginkgo biloba extract+betahistine mesylate tablets.The treatment duration was 7 days.The clinical efficacy,vestibular symptom index(VSI)scores,Berg balance scale(BBS)scores,dizziness handicap inventory(DHI)scores,average blood flow velocity of cerebral arteries[including left vertebral artery(LVA),right vertebral artery(RVA),basilar artery(BA)],recurrence rate after 1 month and 6 months of treatment,and incidence of adverse reactions were compared.Results The overall effective rate of the combination group was 96.00％,which was better than that in the control group(82.00％),the difference was statistically significant(P＜0.05).After 7 days of treatment,VSI and DHI scores of the combination group were(19.08±1.97),(26.04±2.35)points,which were lower than those of the control group[(27.90±2.14),(38.76 ±3.23)points],while the BBS score in the combination group was(53.01±5.22)points,which was higher than that in the control group[(32.48±4.79)points],the differences were statistically significant(P＜0.05).There were no statistically significant differences in average blood flow velocity of cerebral arteries of the two groups after treatment(P＞0.05).There were no statistically significant differences in the inci-dence of adverse reactions and recurrence rate after 1 month of treatment between the two groups(P＞0.05).However,the recurrence rate after 6 months of treatment of the combination group was 6.00％,which was lower than that in the control group(20.00％),the difference was statisti-cally significant(P＜0.05).Conclusion The combination of Epley manual reduction combined with ginkgo biloba extract and betahistine me-sylate tablets is more effective than medication alone in the treatment of otolithiasis vertigo.It can effectively improve the vestibular symptoms and balance function,improve cerebral artery blood flow velocity and quality of life,and decrease the recurrence rate,with good safety.
关键词
耳石症眩晕/Epley手法复位/银杏叶提取物/甲磺酸倍他司汀/复发Key words
Otolithiasis vertigo/Epley manual reduction/Ginkgo biloba extract/Betahistine mesylate/Recurrence引用本文复制引用
基金项目
衡水市科技局支持项目(2019014017Z)
河北省2020年度医学科学研究课题计划项目(20200414)
出版年
2024
NETL
NSTL
维普
万方数据