ⅠA～ⅡA期宫颈癌患者临床病理参数与预后的相关性及发生盆腔淋巴结转移的危险因素分析
Correlation between clinicopathological parameters and prognosis of stage ⅠA-ⅡA cervical cancer patients and analysis of the risk factors of pelvic lymph node metastasis occurred
冷在华 1丁敬 1张秀琼1
作者信息
- 1. 雅安市中医医院妇产科 四川 雅安 625000
- 折叠
摘要
目的 分析ⅠA～ⅡA期宫颈癌患者临床病理参数与预后的相关性及发生盆腔淋巴结转移的危险因素.方法 回顾性选择2017年1月至2018年7月在雅安市中医医院接受治疗的92例ⅠA～ⅡA期宫颈癌患者.统计患者5年总体生存率,比较不同临床病理参数的患者的5年总体生存率,使用多因素Logistic回归分析临床病理参数与预后的关系;记录盆腔淋巴结转移的发生情况,使用单因素和多因素Logistic回归分析盆腔淋巴结转移的危险因素.结果 不同国际妇产科学联合会(FIGO)分期、肿瘤组织学类型、间质浸润深度及有无宫旁浸润、盆腔淋巴结转移、嗜神经侵袭的患者的5年总体生存率比较,差异均有统计学意义(P＜0.05).经多因素Logistic回归分析,ⅠA～ⅡA期宫颈癌患者预后受FIGO分期、肿瘤组织学类型、间质浸润深度、盆腔淋巴结转移的影响(P＜0.05).经单因素分析,不同FIGO分期、肿瘤最大直径、肿瘤分级、间质浸润深度及是否淋巴脉管间隙浸润的ⅠA～ⅡA期宫颈癌患者的盆腔淋巴结转移率比较,差异均有统计学意义(P＜0.05);经多因素Logistic回归分析,肿瘤分级、淋巴脉管间隙浸润和间质浸润深度均是ⅠA～ⅡA期宫颈癌患者发生盆腔淋巴结转移的独立危险因素(P＜0.05).结论 ⅠA～ⅡA期宫颈癌患者的临床病理参数与其预后密切相关,其中盆腔淋巴结转移风险受肿瘤分级、淋巴脉管间隙浸润和间质浸润深度影响,值得临床予以重视.
Abstract
Objective To analyze the correlation between clinicopathological parameters and prognosis of stage ⅠA-ⅡA cervical cancer patients and the risk factors of pelvic lymph node metastasis occurred.Methods Ninety-two patients with stage ⅠA-ⅡA cervical cancer trea-ted at Ya'an Traditional Chinese Medicine Hospital from January 2017 to July 2018 were retrospectively selected.The 5-year overall survival rate was analyzed,different clinical pathological parameters of the patients overall 5 years survival rate,using multiariable was compared.The relation-ship between clinical pathological parameters and prognosis was analyzed using multivariate Logistic regression analysis.The incidence of pelvic lymph node metastasis was recorded,and the risk factors of pelvic lymph node metastasis were analyzed by univariate and multivariate Logistic re-gression.Results There were statistically significant differences in 5-year overall survival rate among patients with different International Federa-tion of Obstetrics and Gynecology(FIGO)stages,tumor histological types,depth of interstitial invasion,paruterine invasion,pelvic lymph node metastasis,and neurotropic invasion(P＜0.05).After multiariable Logistic regression analysis,the prognosis of stage ⅠA-ⅡA cervical cancer patients was influenced by FIGO stage,tumor histologic types,interstitial infiltration depth and pelvic lymph node metastasis(P＜0.05).Ac-cording to univariate analysis,there were statistically significant differences in different FIGO stage,maximum tumor diameter,tumor grade,lymph vessel space infiltration and interstitial infiltration depth may be related to pelvic lymph node metastasis in stage ⅠA-ⅡA cervical cancer patients(P＜0.05).After multiariable Logistic regression analysis,tumor grade,lymph vascular space invasion and stromal infiltration depth were stageⅠA-ⅡA cervical cancer patients independent risk factors for pelvic lymph node metastases(P＜0.05).Conclusion The clinicopathological parameters of stage ⅠA-ⅡA cervical cancer patients are closely related to their prognosis.The risk of pelvic lymph node metastasis is influenced by tumor grading,lymphatic vessel space infiltration,and interstitial infiltration depth,and deserves clinical attention.
关键词
ⅠA～ⅡA期/宫颈癌/病理参数/预后/盆腔淋巴结转移/危险因素Key words
ⅠA-ⅡA/Cervical cancer/Pathological parameters/Prognosis/Pelvic lymph node metastasis/Risk factor引用本文复制引用
基金项目
四川省重点研发计划-一般项目-社会发展领域(2020SZ0050)
出版年
2024
NETL
NSTL
维普
万方数据