Objective To study the effects of different methods combined with radiotherapy on thin keloid and the effects on matrix metal-loproteinases(MMPs),hypoxia inducible factor-1α(HIF-1α),and transforming growth factor-1β(TGF-β1).Methods A total of 62 pa-tients with thoracic and abdominal keloids(94 keloids)admitted to the Department of Plastic Surgery,Affiliated Cancer Hospital of Inner Mongolia Medical University(Inner Mongolia Autonomous Region Cancer Hospital)from October 2020 to September 2022 were selected and divided into la-ser combined with radiotherapy(LCR)group(30 cases,47 keloids)and surgery combined with radiotherapy(SCR)group(30 cases,47 ke-loids)according to different treatment methods.The LCR group received CO2 lattice LCR,and the SCR group received SCR.The clinical efficacy and recurrence rate were observed after 12 months of treatment in the two groups.Changes of patient and observer scar assessment scale(POSAS)score,Vancouver scar scale(VSS)score,cytokines such as matrix metalloproteinase(MMP)-2 and MMP-9,HIF-1α and TGF-β1 in scar tissue before and after 12 months of treatment in two groups.Results The total effective rate of LCR group was 93.62％,which was higher than that of SCR group(76.60％),and the recurrence rate was 4.26％,which was lower than that of SCR group(19.15％),the differences were statistically significant(P＜0.05).After 12 months of treatment,POSAS and VSS scores in LCR group were(23.96±2.64)and(5.28±0.54)points,which were lower than those in SCR group[(33.96±3.59)and(6.55±0.68)points],the differences were statistically significant(P＜0.05).The levels of MMP-2,MMP-9,HIF-1α and TGF-β1 expression in scar tissue of LCR group were 111.65±13.55,106.76±12.68,1.24±0.14,1.10±0.12,which were lower than those in SCR group(127.96±14.71,121.08±14.33,1.55±0.17,1.22±0.13),the differences were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions be-tween the two groups(38.30％vs.46.81％)(P＞0.05).Conclusion LCR and SCR both improve symptoms of thin scar tissue and inhibit scar recurrence,but LCR has a higher cure rate and lower recurrence rate.It has a stronger inhibitory effect on MMPs and HIF-1α,TGF-β1 expression in scar tissue,and is safe,making it worthy of clinical recommendation.
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