Effect of microporous dot matrix laser combined with epidermal growth factor on cosmetic score and skin barrier function in patients with depressed scar of facial acne
Effect of microporous dot matrix laser combined with epidermal growth factor on cosmetic score and skin barrier function in patients with depressed scar of facial acne
Objective To investigate the effect of microporous dot matrix laser combined with epidermal growth factor(rhEGF)on cos-metic score and skin barrier function in patients with acne depression scar.Methods A total of 128 patients with facial depression scars caused by acne who were treated in the Department of Dermatology,Sinopod Tongmei General Hospital from July 2019 to March 2021 were prospectively selected as the study subjects,and divide into the observation group(n=64)and the control group(n=64)according to the random number table method.Both groups received routine nursing intervention,while the control group was only treated with superpulse CO2 dot matrix laser.The observation group was treated with superpulse CO2 dot matrix laser plus rhEGF.Cosmetic score,skin barrier function,acne scar weight(EC-CA)score,scab shedding time and total treatment effectiveness were compared between the two groups before treatment and 6 weeks after treat-ment.Results The subjective beauty score,the objective score of observation group were(20.33±3.48),(22.37±3.18)points,which were significantly higher than those of control group[(16.66±2.49),(17.22±2.26)points],the differences were statistically significant(P＜0.05).After 6 weeks of treatment,the oil value and epidermal water loss of the observation group patients were(56.42±2.98)AU and(18.51±2.03)g/(h·m2),respectively,which were significantly lower than the control group[(60.58±3.21)AU and(25.15±3.07)g/(h·m2)],and the skin water content was(49.12±4.37)AU,which was significantly higher than the control group[(43.56±3.12)AU],the differences were statistically significant(P＜0.05).After 6 weeks of treatment,the ECCA score of the observation group patients was(11.11±2.15)points,which was significantly lower than that of the control group[(21.98±4.22)points],and the average peeling time was(6.55±0.67)days,which was shorter than that of the control group[(8.99±1.09)days],the differences were statistically significant(P＜0.05).The total effective rate of the observation group was 67.19％,which was significantly higher than that of the control group(48.44％),the differ-ences were statistically significant(P＜0.05).Conclusion Compared to using microporous lattice laser therapy alone,microporous dot matrix laser combined with rhEGF can significantly improve cosmetic scores and skin barrier function,accelerate skin recovery and improve clinical effica-cy in the treatment of patients with depressed facial acne scars,and is a treatment method worth promoting.
关键词
面部痤疮凹陷性瘢痕/微孔点阵激光/生长因子/美容评分/皮肤屏障功能
Key words
Depressed scar of facial acne/Microporous dot matrix laser/Epidermal growth factor/Beauty score/Skin barrier function
维普
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