摘要
目的 探讨子宫肌瘤治疗中不同子宫动脉介入栓塞(UAE)材料的临床疗效及对子宫血供和卵巢功能的影响.方法 回顾性选取2021年2月至2023年2月衡水市哈励逊国际和平医院收治的子宫肌瘤患者80例,依据不同UAE材料分为聚乙烯醇(PVA)组、平阳霉素碘化油乳剂(PLE)组,每组各40例.对比观察两组患者的子宫肌瘤体积、子宫体积、心理状态、生活质量[生存质量测定量表简表(QOL-BREF)评分]、实验室指标[血红蛋白、肿瘤特异性生长因子(TSGF)、胰岛素样生长因子-1(IGF-1)]、子宫血供[最粗供血动脉管径、收缩期峰值血流速度(Vs)、平均流速(Vm)、阻力指数]、卵巢功能[促黄体生成素(LH)、促卵泡生成素(FSH)、孕酮、雌二醇]、临床疗效、术后综合征发生情况、复发情况.结果 治疗后,两组患者的子宫肌瘤体积、子宫体积、焦虑评分、抑郁评分、QOL-BREF评分、血红蛋白、TSGF、IGF-1、最粗供血动脉管径、Vs、Vm、阻力指数、LH、FSH、P、E2水平之间的差异均无统计学意义(P＞0.05).PVA组与PLE组患者的治疗总有效率(92.50％vs.90.00％)比较,差异无统计学意义(P＞0.05).PVA组患者的术后综合征发生率为35.00％,明显低于PLE组(62.50％),差异有统计学意义(P＜0.05).PVA组患者的复发率为0,明显低于PLE组(15.00％),差异有统计学意义(P＜0.05).结论 子宫肌瘤治疗中采用PVA和PLE进行UAE治疗的临床疗效相当,对子宫血供的影响相当,均不会对卵巢功能造成影响.栓塞剂选择PVA术后综合征总发生率和复发率低于 PLE.
Abstract
Objective To explore the clinical efficacy of different uterine artery embolization(UAE)materials in the treatment of uterine fibroids and their impact on uterine blood supply and ovarian function.Methods A retrospective selection was conducted on 80 patients with uter-ine fibroids who were admitted to Hengshui Harison International Peace Hospital from February 2021 to February 2023.They were divided into two groups based on different UAE materials:polyvinyl alcohol(PVA)group and pingyangmycin iodized oil emulsion(PLE)group,with 40 cases in each group.The volume of uterine fibroids,uterine volume,psychological status,quality of lifequality of life brief scale(QOL-BREF)score],laboratory indicators[hemoglobin,tumor specific growth factor(TSGF),insulin like growth factor-1(IGF-1)],uterine blood supply[diameter of the thickest supplying artery,systolic velocity(Vs),average velocity(Vm),resistance index],ovarian function[luteinizing hormone(LH),follicle stimulating hormone(FSH),progesterone,estradiol],clinical efficacy,incidence of postoperative syndrome,and recurrence between two groups of patients were compared and observed.Results There were no statistically significant differences in the volume of uterine fibroids,uter-ine volume,anxiety score,depression score,QOL-BREF score,hemoglobin,TSGF,IGF-1,diameter of the thickest supplying artery,Vs,Vm,RI,LH,FSH,progesterone,and estradiol levels between the two groups of patients(P＞0.05).There was no statistically significant difference in the total effective rate between the PVA group and the PLE group(92.50％vs.90.00％)(P＞0.05).The incidence of postopera-tive syndrome in the PVA group patients was 35.00％,which was significantly lower than that in the PLE group patients(62.50％),and the difference was statistically significant(P＜0.05).The recurrence rate of patients in the PVA group was 0,which was significantly lower than that in the PLE group(15.00％),and the difference was statistically significant(P＜0.05).Conclusion The clinical efficacy of using PVA and PLE for UAE treatment in the treatment of uterine fibroids is comparable,with a similar impact on uterine blood supply and no impact on ovarian function.The overall incidence and recurrence rate of PVA postoperative syndrome are lower than those of PLE when choosing embol-ic agents.
维普
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