临床和实验医学杂志2024，Vol.23Issue(12) ：1261-1265.DOI:10.3969/j.issn.1671-4695.2024.12.008

升陷汤加味联合酒石酸美托洛尔治疗气虚下陷型室性早搏患者的疗效及其对心电图指标及心率震荡的影响

Efficacy of modified Shengxian Decoction combined with metoprolol tartrate in the treatment of patients with Qi deficiency depression type ventricular premature beats and its effect on electrocardiogram indexes and heart rate oscillation

许国磊 孙雪松 吴欣芳 吴宝
临床和实验医学杂志2024，Vol.23Issue(12) ：1261-1265.DOI:10.3969/j.issn.1671-4695.2024.12.008
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升陷汤加味联合酒石酸美托洛尔治疗气虚下陷型室性早搏患者的疗效及其对心电图指标及心率震荡的影响

Efficacy of modified Shengxian Decoction combined with metoprolol tartrate in the treatment of patients with Qi deficiency depression type ventricular premature beats and its effect on electrocardiogram indexes and heart rate oscillation

许国磊 1孙雪松 2吴欣芳 1吴宝1
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作者信息

  • 1. 中国中医科学院广安门医院南区心血管科 北京 102600
  • 2. 中国中医科学院广安门医院南区呼吸科 北京 102600
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摘要

目的 探讨升陷汤加味联合酒石酸美托洛尔治疗气虚下陷型室性早搏患者的疗效及其对心电图指标和心率震荡的影响.方法 选择2019年8月至2023年1月中国中医科学院广安门医院接收的160例气虚下陷型室性早搏患者为研究对象进行前瞻性研究,根据随机数字表法将其分为中西组和对照组,每组各80例.对照组采用酒石酸美托洛尔治疗,中西组采用酒石酸美托洛尔+升陷汤加味治疗,均连续用药8周.比较两组总有效率,治疗前、治疗8周后的中医证候积分、室性早搏发作次数、心电图指标、心率震荡参数及不良反应情况.结果 治疗8周后,中西组总有效率为93.75％,明显高于对照组(80.00％),差异有统计学意义(P＜0.05).治疗8周后,两组证候积分、室性早搏发作次数均较治疗前显著下降,且中西组的证候积分、室性早搏发作次数分别为(6.61±0.83)分、(112.61±13.83)次/h,显著低于对照组[(10.05±1.32)分、(151.05±17.32)次/h],差异均有统计学意义(P＜0.05).治疗8周后,两组PR间期均较治疗前显著缩短,QRS波时限、QTc间期均较治疗前显著延长,且中西组的PR间期为(0.132±0.014)ms,显著短于对照组[(0.141±0.016)ms],QRS波时限、QTc间期分别为(0.093±0.013)、(0.496±0.052)s,均显著长于对照组[(0.082±0.011)、(0.433±0.047)s],差异均有统计学意义(P＜0.05).治疗8周后,两组T0水平均较治疗前显著下降,TS水平均较治疗前显著上升,且中西组的T0水平为(0.09±0.02)％,显著低于对照组[(0.21±0.05)％],TS水平为(5.72±0.83)ms/RR,显著高于对照组[(4.45±0.66)ms/RR],差异均有统计学意义(P＜0.05).中西组与对照组的总不良反应发生率比较,差异无统计学意义(P＞0.05).结论 采用升陷汤加味联合酒石酸美托洛尔治疗气虚下陷型室性早搏患者可有效减少患者早搏次数,调节心功能,效果较为理想,临床应用价值较高.

Abstract

Objective To explore the efficacy of modified Shengxian Decoction combined with metoprolol tartrate in the treatment of Qi deficiency depression type ventricular premature beats and its effect on electrocardiogram indexes and heart rate oscillation.Methods A total of 160 patients with Qi deficiency depression type ventricular premature beats accepted by Guang'anmen Hospital,China Academy of Chinese Medi-cine Sciences from August 2019 to January 2023 were prospectively selected as the research objects.They were divided into the Chinese and West-ern medicine group and the control group according to the random number table method,with 80 cases in each group.The control group was trea-ted with metoprolol tartrate,while the Chinese and Western medicine group was treated with metoprolol tartrate and modified Shengxian Decoction.Both groups were treated continuously for 8 weeks.The total effective rate,traditional Chinese medicine syndrome score,frequency of ventricular premature beats,electrocardiogram indicators,heart rate oscillation parameters before treatment and after 8 weeks of treatment,and adverse reac-tion of the two groups were compared.Results After 8 weeks of treatment,the total effective rate of the Chinese and Western medicine group was 93.75％,which was obviously higher than that of the control group(80.00％),the difference was statistically significant(P＜0.05).After 8 weeks of treatment,the syndrome scores and the number of ventricular premature beats in the two groups were significantly lower than those before treatment,and the syndrome scores and the number of ventricular premature beats in the Chinese and Western group were(6.61±0.83)points and(112.61±13.83)times/h,respectively,which were significantly lower than those in the control group[(10.05±1.32)points,(151.05±17.32)times/h],the differences were statistically significant(P＜0.05).After 8 weeks of treatment,the PR interval of the two groups were significantly shorter than those before treatment,the QRS wave duration and QTc interval were significantly longer than those before treatment,and the PR interval of the Chinese and Western group was(0.132±0.014)ms,which was significantly shorter than that of the control group[(0.141±0.016)ms],the QRS wave duration and QTc interval were(0.093±0.013)and(0.496±0.052)s,respectively,which were significantly longer than those of the control group[(0.082±0.011)and(0.433±0.047)s],the differences were statistically significant(P＜0.05).Af-ter 8 weeks of treatment,the levels of T0 in the two groups were significantly lower than those before treatment,and the levels of TS were signifi-cantly higher than those before treatment,the level of T0 in the Chinese and Western group was(0.09±0.02)％,which was significantly lower than that in the control group[(0.21±0.05)％],the level of TS was(5.72±0.83)ms/RR,which was significantly higher than that in the control group[(4.45±0.66)ms/RR],and the differences were statistically significant(P＜0.05).There was no statistically significant obvi-ous difference in the incidence of adverse reaction between the two groups(P＞0.05).Conclusion The treatment of patients with ventricular premature beats using modified Shengxian Decoction combined with metoprolol tartrate can effectively reduce the number of premature beats,regu-late cardiac function,and achieve ideal results.The clinical application value is high.

关键词

室性早搏/升陷汤加味/酒石酸美托洛尔/心电图指标/心率震荡

Key words

Ventricular premature beats/Modified Shengxian Decoction/Metoprolol tartrate/Eelectrocardiogram indicators/Heart rate oscillation

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基金项目

中国中医科学院广安门医院南区院级科研基金课题(Y2021-06)

出版年

2024
临床和实验医学杂志
首都医科大学附属北京友谊医院

临床和实验医学杂志

CSTPCD
影响因子：1.504
ISSN：1671-4695
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