摘要
目的 观察不同严重程度干眼患者的角膜地形图测量结果的可重复性.方法 回顾性收集2023年8月至12月就诊于航天中心医院眼科门诊的干眼患者53例作为观察组,将其按照严重程度分为轻度干眼组(n=16)、中度干眼组(n=21)、重度干眼组(n=16),另选取无干眼症状及干眼症相关病史的健康者20名作为对照组.所有患者进行检查,完成常规干眼检查[泪膜破裂时间(TBUT)、泪膜脂质层厚度(LLT)、非接触泪膜破裂时间(NIKBUT)、角膜荧光素染色(cCFS)、Schirmer试验、眼表疾病指数(OSDI)评分],并在30 min内使用进行3次角膜地形图测量,双眼均计入统计.测量结果运用计算组内相关系数(ICC)进行比较,观察两组角膜地形图测量结果中平坦曲率(K1)、轴位1、陡峭曲率(K2)、轴位2、最大角膜曲率(Kmax)、上下方平均屈光度差值(IS)、平面e、斜面e、8 mm凹陷指数、角膜表面非对称性指数(SAI)可重复性.结果 观察组的TBUT、LLT、NIKBUT、Schirmer试验均低于对照组,CFS、OSDI评分均高于对照组,差异均有统计学意义(P＜0.05).重症干眼患者K2、其所对应轴位及Kmax可重复性较差,差异均无统计学意义(P＞0.05);重症干眼患者K1、轴位1、IS、平面e、斜面e、8 mm凹陷指数、SAI各项可重复性较好,差异均有统计学意义(P＜0.05).结论 轻、中度干眼患者所有CCs可重复性较好,重度干眼患者的角膜地形图测量结果可重复性差.白内障术前干眼治疗可提高晶体测量的准确性,特别是对屈光性白内障手术晶体的测算更有意义.
Abstract
Objective To observe the reproducibility of corneal topography measurements in patients with dry eye of varying severity.Methods A total of 53 dry eye patients who visited the Department of ophthalmology outpatient,Aerospace Center Hospital from August to De-cember 2023 were retrospectively collected as the observation group.They were divided into mild dry eye group(n=16),moderate dry eye group(n=21),and severe dry eye group(n=16)according to their severity.Additionally,20 healthy individuals without dry eye symptoms or a history of dry eye related diseases were selected as the control group.All patients underwent examinations and completed routine dry eye examina-tions[tear film breakup time(TBUT),tear film lipid layer thickness(LLT),noninvasive keratographic tear break up time(NIKBUT),corneal fluorescence staining(cCFS),Schirmer test,ocular surface disease index(OSDI)score].All patients were measured with 3 corneal topography measurements within half an hour,both eyes were included in the statistics.And the measurement results were compared with the correlation coef-ficient(ICC)within the calculation group,and the repeatability of Keratometry1(K1),axial 1,Keratometry2(K2),axial 2,Keratometry max(Kmax),inferior-superior(IS)between the upper and lower parts,plane e,oblique e,8 mm depression index,and corneal surface asymmetry index(SAI)were observed in the measurement results of the two corneal topographic maps.Results The TBUT,LLT,NIKBUT,and Schirmer tests of the observation group were lower than those of the control group,the CFS and OSDI scores were higher than those of the control group,and the differences were statistically significant(P＜0.05).The reproducibility of all CCs in the control group and patients with mild and moderate dry eye was statistically significant(P＜0.05).The reproducibility of K2,its corresponding axis,and Kmax in severe dry eye patients was poor,and the differences were not statistically significant(P＞0.05);the reproducibility of K1,axis 1,IS,plane e,oblique e,8 mm depression in-dex,and SAI in severe dry eye patients was good,and the differences were statistically significant(P＜0.05).Conclusion The reproducibility of all CCs in patients with mild and moderate dry eye was better,corneal topography measurements in patients with severe dry eye are not reproduc-ible.Preoperative dry eye treatment for cataracts can improve the accuracy of lens measurements,especially for refractive cataract surgical lenses.
基金项目
航天医疗健康科技集团2022年科研立项(2022YK28)
NETL
NSTL
万方数据