摘要
目的 对多囊卵巢综合征(PCOS)并发代谢综合征患者的抗米勒管激素(AMH)、载脂蛋白(Apo)B与ApoA1比值(ApoB/ApoA1)及维生素D的水平进行检测,并探究其临床意义.方法 回顾性选取2021年1月至2024年2月宣城市人民医院收治的40例PCOS合并代谢综合征患者为研究组,另选取40例单纯PCOS患者为对照组.比较两组间AMH、ApoB/ApoA1及维生素D水平差异,并对患者的临床资料(年龄、初潮年龄、收缩压、舒张压、体重指数)进行对比,采用多因素Logistic回归分析对影响PCOS患者并发代谢综合征的因素进行分析,并采用受试者操作特征(ROC)曲线评估不同指标诊断PCOS患者并发代谢综合征的效能.结果 研究组患者的AMH、ApoB/ApoA1水平分别为(15.45±4.89)ng/mL、1.12±0.31,均高于对照组[(5.22±0.56)ng/mL、0.68±0.16],维生素 D 水平为(11.68±1.25)ng/mL,低于对照组[(20.12±3.16)ng/mL],差异均有统计学意义(P＜0.05).两组间年龄、初潮年龄、收缩压比较,差异均无统计学意义(P＞0.05),研究组患者的舒张压、体重指数分别为(80.78±9.46)mmHg、(28.26±4.13)kg/m2,均高于对照组[(75.12±8.79)mmHg、(24.56±2.65)kg/m2],差异均有统计学意义(P＜0.05).经多元 Logis-tic 回归分析可知AMH、ApoB/ApoA1、维生素D均会影响PCOS患者并发代谢综合征,对PCOS患者并发代谢综合征具有较高的诊断价值,其曲线下面积(AUC)值分别为0.958、0.892、0.993.结论 AMH、ApoB/ApoA1比值和维生素D在PCOS患者中具有重要的临床意义,而且这些指标的变化与PCOS患者并发代谢综合征的代谢状况密切相关,并可作为诊断PCOS患者并发代谢综合征的有效生物标志物.
Abstract
Objective To investigate the levels and clinical significance of anti-Müllerian hormone(AMH),the ratio of apolipoprotein(Apo)B to ApoA1(ApoB/ApoA1),and Vitamin D in patients with polycystic ovary syndrome(PCOS)concomitant with metabolic syndrome.Methods Forty patients with PCOS complicated with metabolic syndrome admitted to Xuancheng People's Hospital from January 2021 to February 2024 were retrospectively selected as the study group,and another 40 patients with simple PCOS were selected as the control group.The levels of AMH,ApoB/ApoA1,and Vitamin D were compared between the two groups,the clinical data of the patients(age,age at menarche,systolic blood pressure,diastolic blood pressure,body mass index)were compared.The factors affecting the concurrent metabolic syndrome in PCOS pa-tients were analyzed using multivariate Logistic regression analysis,and the efficacy of different indicators in diagnosing metabolic syndrome in P-COS patients was evaluated using receiver operating characteristic(ROC)curves.Results The levels of AMH and ApoB/ApoA1 in the study group were(15.45±4.89)ng/mL and 1.12±0.31,respectively,which were higher than those in the control group[(5.22±0.56)ng/mL and 0.68±0.16],the level of Vitamin D was(11.68±1.25)ng/mL,which was lower than those in the control group[(20.12±3.16)ng/mL],and the differences were statistically significant(P＜0.05).There were no statistically significant differences in the levels of luteinizing hormone,follicle stimulating hormone,prolactin,and estrogen between the two groups of patients(P＞0.05).There were no statistically signifi-cant differences in age,menarche age,and systolic blood pressure between the two groups(P＞0.05).The diastolic blood pressure and body mass index of the study group patients were(80.78±9.46)mmHg and(28.26±4.13)kg/m2,respectively,which were higher than those of the control group[(75.12±8.79)mmHg and(24.56±2.65)kg/m2],and the differences were statistically significant(P＜0.05).Multiva-riate Logistic regression analysis revealed that AMH,ApoB/ApoA1,and Vitamin D levels influence the co-occurrence of metabolic syndrome in patients and have a high diagnostic value for metabolic syndrome with respective area under the curve(AUC)values of 0.958,0.892,and 0.993.Conclusion AMH,the ApoB/ApoA1 ratio,and Vitamin D not only hold significant clinical importance in patients with PCOS but also are closely related to the metabolic status in patients with concurrent metabolic syndrome,serving as effective biomarkers for diagnosing metabolic syndrome in PCOS patients.
基金项目
安徽省高校自然科学研究项目(KJ2020A0446)
NETL
NSTL
万方数据