Correlation between Helicobacter pylori infection and serum hypoxic-inducing factor-1α and reactive oxygen species expression in pa-tients with gastric cancer
Correlation between Helicobacter pylori infection and serum hypoxic-inducing factor-1α and reactive oxygen species expression in pa-tients with gastric cancer
Objective To investigate the correlation between serum hypoxia-inducing factor-1α(HIF-1α)and reactive oxygen spe-cies expression levels and Helicobacter pylori(Hp)infection in patients with gastric cancer.Methods Sixty patients with gastric cancer and gas-tritis in Daqing Oilfield General Hospital from September 2019 to September 2023 were retrospectively selected and divided into three groups ac-cording to disease types:the gastric cancer group,the non-atrophic gastritis group and the chronic chronic atrophic gastritis group,with 20 cases in each group.The expression levels of serum reactive oxygen species and HIF-1α in the three groups were statistically analyzed,and the expres-sion levels of serum HIF-1α and reactive oxygen species in the three groups of patients with different clinical characteristics and their correlation were statistically analyzed.Results The levels of serum HIF-1α and reactive oxygen species in the gastric cancer group were(248.04±41.36)and(3 361.50±512.23)μmol/L,respectively,the levels of serum HIF-1α and reactive oxygen species in the chronic atrophic gastritis group were(231.25±36.21)μmol/L and(3 079.76±502.12)μmol/L,respectively,which were higher than those in chronic non-atrophic gastri-tis group[(180.45±30.41)μmol/L,(2 599.07±412.63)μmol/L],the differences were statistically significant(P＜0.05).There were no statistically significant differences in serum HIF-1α and reactive oxygen species levels between patients of different ages and genders(P＞0.05);the levels of serum HIF-1α and reactive oxygen species in Hp-positive patients in the gastric cancer group and the chronic atrophic gas-tritis group were higher than those in Hp-negative patients,and the differences were statistically significant(P＜0.05);there were no statisti-cally significant differences in serum HIF-1α and reactive oxygen species levels between Hp-positive patients and Hp-negative patients in the chronic non-atrophic gastritis group(P＞0.05).The expression levels of serum reactive oxygen species and HIF-1α in the chronic atrophic gastritis group and the gastric cancer group were significantly positively correlated(r=0.712,P＜0.05).Conclusion Hp infection is signifi-cantly correlated with serum HIF-1α and reactive oxygen species expression levels in patients with gastric cancer.Hp infection can promote the occurrence and development of gastric cancer by up-regulating serum HIF-1α and reactive oxygen species expression levels.This provides effec-tive evidence for clinical diagnosis and treatment.
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