Objective To investigate the expression of T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif do-main(TIGIT)in peripheral blood CD4+T lymphocytes and CD8+T lymphocytes in multiple myeloma and its clinical significance.Methods Forty-seven newly diagnosed multiple myeloma patients admitted to the Department of Hematology,the First Affiliated Hospital of Naval Medical University from March 2022 to July 2023 were prospectively collected as the multiple myeloma group.At the same time,40 age-matched volun-teers who were healthy in the physical examination center of our hospital during the same period were selected as the control group.The expression of TIGIT on CD4+T and CD8+T lymphocytes was detected by flow cytometry,and the correlation between the expression level of TIGIT on CD4+T lymphocytes and CD8+T lymphocytes and clinical characteristics of multiple myeloma patients and clinical test indicators was analyzed.Results The expression level of TIGIT in CD4+T lymphocytes and CD8+T lymphocytes in multiple myeloma group were(24.57±6.29)％,(42.87±5.71)％,which were higher than those in the control group[(9.18±3.06)％,(11.29±2.23)％],the differences were statistically signifi-cant(P＜0.05).The level of TIGIT expression on CD4+T lymphocytes and CD8+T lymphocytes was correlated with DS stage,and the level of TIGIT expression on CD4+T lymphocytes and CD8+T lymphocytes in peripheral blood of patients with DS stage Ⅲ was significantly higher than that of patients with stage Ⅰ-Ⅱ,the differences were statistically significant(P＜0.05).There were no statistically significant differences in age,sex,ISS stage,kidney damage,blood phosphorus,bone destruction and urinary weekly protein(P＞0.05).The expression level of TIGIT on CD4+T lymphocytes and CD8+T lymphocytes was positively correlated with hemoglobin(r=0.302,0.354;P＜0.05),and negatively cor-related with β2 microglobulin(r=-0.284,-0.296;P＜0.05).Conclusion The expression of TIGIT in CD4+T lymphocytes and CD8+T lymphocytes is increased in patients with multiple myeloma,and the expression is closely related to DS stage,hemoglobin and β2 microglobulin.
维普
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