摘要
目的 研究微RNA-27(miR-27)、脂蛋白(a)[LP(a)]、糖化白蛋白(GA)与糖尿病血管并发症(DVC)的相关性.方法 前瞻性选取2020年2月至2022年2月于沧州市人民医院治疗的2型糖尿病(T2DM)患者100例,按照并发症情况分别纳入无糖尿病并发症组(n=25)、糖尿病下肢血管病变组(n=35)及糖尿病肾病组(n=40).纳入本院体检中心同时期健康体检者20名为对照组.比较4组临床资料;血清总胆固醇、甘油三酯、HDL-C、LDL-C、FPG、HbA1c等常规生化指标;血清LP(a)、GA、miR-27等指标水平;导致DVC发生的影响因素;分析DVC患者临床资料及总胆固醇、甘油三酯、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、空腹血糖、糖化血红蛋白(HbA1c)、LP(a)、GA、miR-27等指标与DVC的相关性.结果 无糖尿病并发症组、糖尿病下肢血管病变组、糖尿病肾病组的体重指数、总胆固醇、甘油三酯、HDL-C、LDL-C、FPG、HbA1c、LP(a)、GA、miR-27均高于对照组,差异均有统计学意义(P＜0.05).糖尿病下肢血管病变组、糖尿病肾病组的T2DM病程、总胆固醇、甘油三酯、HDL-C、LDL-C、FPG、HbA1c、LP(a)、GA、miR-27均高于无糖尿病并发症组,糖尿病肾病组的T2DM病程、总胆固醇、甘油三酯、HDL-C、LDL-C、FPG、HbA1c、LP(a)、GA、miR-27均高于糖尿病下肢血管病变组,差异均有统计学意义(P＜0.05).T2DM病程、LP(a)、GA、miR-27 为导致 DVC 发生的独立危险因素(OR=1.723,95％CI:1.559～2.318;OR=1.978,95％CI:1.658～2.574;OR=1.916,95％CI:1.620～2.539;OR=1.660,95％CI:1.549～2.214;P＜0.05).经 Pearson 相关分析,T2DM 病程及 LP(a)、GA、miR-27 水平与 DVC 正相关(r=0.865、0.773、0.806、0.957,P＜0.05).结论 T2DM 病程、LP(a)、GA、miR-27水平与DVC正相关.
Abstract
Objective To investigate the correlation between microRNA-27(miR-27),lipoprotein(a)[LP(a)],glycated albumin(GA)and diabetic vascular complication(DVC).Methods A total of 100 patients with type 2 diabetes mellitus(T2DM)who were treated in Cangzhou People's Hospital from February 2020 to February 2022 were prospectively selected and included in without diabetic complications group(n=25),diabetic lower extremity vascular disease group(n=35)and diabetic nephropathy group(n=40)according to the different compli-cations.Twenty healthy subjects in physical examination center of the same hospital at the same time were included as control group.The clinical data of the four groups were compared.Serum total cholesterol,triglyceride,HDL-C,LDL-C,FPG,HbA1c and other conventional biochemi-cal indexes;Serum LP(a),GA,miR-27 and other indexes;The influencing factors leading to DVC;Clinical data of DVC patients and the cor-relation between total cholesterol,triglyceride,high-density lipoprotein(HDL-C),low-density lipoprotein(LDL-C),fasting blood glucose(FPG),glycated hemoglobin(HbA1c),LP(a),GA,miR-27 and other indexes with DVC were analyzed.Results The body mass index,to-tal cholesterol,triglyceride,HDL-C,LDL-C,FPG,HbA1 c,LP(a),GA and miR-27 in the non-diabetic complication group,diabetic lower extremity vascular disease group and diabetic nephropathy group were higher than those in the control group,and the differences were statisti-cally significant(P＜0.05).The course of T2DM,total cholesterol,triglyceride,HDL-C,LDL-C,FPG,HbA1c,LP(a),GA and miR-27 in diabetic lower extremity vascular disease group and diabetic nephropathy group were higher than those in non-diabetic complication group,the course of T2DM,total cholesterol,triglyceride,HDL-C,LDL-C,FPG,HbA1c,LP(a),GA and miR-27 in diabetic nephropathy group were higher than those in diabetic lower extremity vascular disease group,and the differences were statistically significant(P＜0.05).The course of T2DM,LP(a),GA and miR-27 were independent risk factors for DVC(OR=1.723,95％CI:1.559-2.318;OR=1.978,95％CI:1.658-2.574;OR=1.916,95％CI:1.620-2.539;OR=1.660,95％CI:1.549-2.214;P＜0.05).Pearson correlation analy-sis showed that the disease course of T2DM and the levels of LP(a),GA and miR-27 were positively correlated with DVC(r=0.865,0.773,0.806,0.957,P＜0.05).Conclusion The course of T2DM and the levels of LP(a),GA and miR-27 are positively correlated with DVC.
维普
万方数据