Objective To investigate the expression and significance of thymus stromal lymphocyte opoietin(TSLP),hypoxia-inducing factor 1α(HIF-1α)and nuclear factor-κB receptor activating factor ligand(RANKL)in the crevicular fluid of patients with periimplantitis(PI)after dentural restoration.Methods A total of 86 patients with denture restoration admitted to the Fifth People's Hospital of Datong from Au-gust 2019 to August 2023 were selected as the study objects.According to whether PI occurred three months after surgery,the patients were divid-ed into good prognosis group(n=61)and poor prognosis group(n=25).The clinical data of the two groups were compared,and the levels of TSLP,HIF-1α and RANKL in the preoperative creval fluid were compared.Multivariate Logistic regression analysis was used to analyzed the re-lationship between gingival crevicular fluid.TSLP,HIF-1α and RANKL levels and postoperative PI in patients with denture restoration.The prognostic value of TSLP,HIF-1α and RANKL in patients with denture restoration was analyzed by receiver operating characteristic(ROC)curve.Results There were no statistically differences in clinical data(gender,age,course of disease,reason for implant and number of im-plants)between the two groups(P＜0.05).The levels of TSLP,HIF-1α and RANKL in the good prognosis group were(122.57±11.30)ng/L,(417.79±115.43)ng/mL and(116.02±13.45)pg/μL,which were significantly lower than those in the poor prognosis group[(138.93±12.70)ng/L,(576.55±177.60)ng/mL,and(133.24±15.69)pg/μL],the differences were statistically significant(P＜0.05).Multi-variate Logistic regression analysis of the prognosis of patients with denture restoration showed that the level of TSLP and HIF-1α in gingival crevi-cultural fluid increased and HIF-1α increased and elevated RANKL levels were independent risk factors for PI in patients with denture restoration(OR=1.119,95％CI:1.048-1.195;OR=1.007,95％CI:1.002-1.013;OR=1.065,95％CI:1.016-1.117;P＜0.05).ROC curve analysis of the levels of TSLP,HIF-1α and RANKL in gingival creval fluid predicted the prognosis of patients with prosthesis restoration,and the results showed that the area under the curve(AUC)values were 0.833,0.786 and 0.809,respectively.Among them,RANKL had the highest specificity(0.852),while HIF-1α had the highest sensitivity(0.800),had good predictive value(P＜0.05).Conclusion The ele-vated levels of TSLP,HIF-1α and RANKL in the creval fluid are independent risk factors for postoperative PI in patients with denture restoration,and all of them have high prognostic value in patients with denture restoration.
维普
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