Objective To explore the diagnostic value of color Doppler flow imaging(CDFI)for neonatal traumatic brain injury.Meth-ods The clinical data of newborns with suspected craniocerebral injury in Bengbu First People's Hospital were selected for retrospective analysis during the period of January 2021 to December 2023,totaling 63 cases;60 newborns diagnosed with craniocerebral injury were classified into 40 cases of mild cerebral injury,10 cases of moderate cerebral injury,10 cases of severe cerebral injury group,and the newborns in the healthy con-trol group were the normal newborns who had no craniocerebral injury in our hospital during the same period,totaling 20 cases.Intracranial MRI(clinical diagnosis)and ultrasonography were performed on the newboms to compare the accuracy of the two diagnostic methods and the diagnosis of different types of brain injury;the resistance index(RI),peak systolic flow velocity(PSV),and pulsatility index(PI)of the central branch of the middle cerebral artery were recorded.Results Among the 63 neonates with craniocerebral injury,58 cases were positive,5 cases were neg-ative.There was no significant difference in the accuracy of clinical diagnosis or MRI diagnosis and craniocerebral ultrasound in neonatal cranioce-rebral injury(P>0.05).Hypoxic-ischemic encephalopathy,intraventricular hemorrhage and brain edema were the main types of neonatal craniocerebral injury according to clinical diagnosis or cranial MRI diagnostic criteria.There was no significant difference in the detection rate of clinical diagnosis or MRI and ultrasonography among different types of injury(P>0.05).The RI and PI of neonates in the mild brain injury group were 0.72±0.07 and 5.89±0.08,respectively.The RI and PI of neonates in the moderate brain injury group were 0.80±0.07 and 5.40±0.07,respectively.The RI and PI of neonates in the severe brain injury group were 0.85±0.08 and 5.04±0.06,respectively,which were significantly higher than those in the control group(0.61±0.05 and 6.18±0.10),the PSV of neonates in the mild brain injury group,moderate brain injury group and severe brain injury group were(37.28±3.71),(34.36±3.52)and(30.12±3.08)cm/s,respectively,which were significantly lower than those in the control group[(40.10±4.06)cm/s],and the differences were statistically significant(P<0.05).RI and PI of neonates in severe brain injury group were higher than those in mild brain injury group and moderate brain injury group,PSV of neonates in severe brain injury group was lower than that in mild brain injury group and moderate brain injury group,the differences were statistically signifi-cant(P<0.05).Conclusion Intracranial ultrasound is more clinically diagnostic or MRI diagnostic positive test can be clear craniocerebral in-jury neonatal hemodynamic changes to determine the severity of brain injury,so the detection of neonatal craniocerebral injury more advocate the application of craniocerebral ultrasound detection.