Objective To investigate the clinical value of albumin(ALB)to alkaline phosphatase(ALP)ratio(AAPR)in the predic-tion of hepatitis B cirrhosis.Methods A total of 100 patients with chronic hepatitis B virus(HBV)infection admitted to Huangshan People's Hospital from August 2019 to December 2020 were retrospectively selected.According to different types of diseases,patients with chronic hepatitis B were divided into the hepatitis B group(n=54)and patients with chronic hepatitis B cirrhosis were divided into the hepatitis B cirrhosis group(n=46).Meanwhile,50 healthy patients admitted during the same period for physical examination were selected as the healthy group.The ALB level,ALP level and AAPR of the three groups were compared.According to the expression of HBV-DNA,46 patients in the hepatitis B cirrhosis group were divided into the positive group(n=23)and the negative group(n=23),and ALB,ALP and AAPR of the two groups were com-pared.The clinical value of AAPR in the prediction of hepatitis B cirrhosis was analyzed using the receiver operating characteristic(ROC)curve.Results The ALB and AAPR in the hepatitis B cirrhosis group were(33.61±8.53)g/L and 0.36±0.14,respectively,which were signifi-cantly lower than those in the hepatitis B group[(43.98±4.87)g/L,0.54±0.14]and the healthy group[(47.25±2.62)g/L,0.69±0.17],the ALP in the hepatitis B cirrhosis group was(116±57)U/L,which was significantly higher than that in the hepatitis B group[(86±25)U/L]and the healthy group[(72±14)U/L],and the differences were statistically significant(P＜0.05).The ALB and AAPR in the hepatitis B group were significantly lower than those in the healthy group,and the ALP level was significantly higher than that in the healthy group,the differences were statistically significant(P＜0.05).The ALB and AAPR of positive patients were(30.57±6.98)g/L and 0.30±0.13,which were lower than those of negative patients[(35.86±8.95)g/L and 0.39±0.16],and the ALP level was(135±71)U/L,which was higher than that of negative patients[(97±31)U/L],the differences were statistically significant(P＜0.05).ROC curve analysis showed that the area under the curve of AAPR in the predicted of hepatitis B cirrhosis was 0.802,higher than ALB(0.721)and ALP(0.736).Conclusion AAPR has significant clinical value in the prediction of hepatitis B cirrhosis and can provide a reference for the diagnosis of hepatitis B cirrhosis in the early stage.
关键词
乙型肝炎/肝硬化/白蛋白与碱性磷酸酶比值/预测
Key words
Hepatitis B/Cirrhosis/Albumin to alkaline phosphatase ratio/Prediction
维普
万方数据