Objective To investigate the effect of self-expanding stent-assisted coil embolization and simple coil embolization in the treatment of large or giant intracranial aneurysms.Methods A total of 180 patients with large or giant intracranial aneurysms admitted to Guan-gyuan Central Hospital from January 2018 to December 2021 were retrospectively selected as the research objects.According to different treatment methods,they were divided into the combined group(n=98)and the control group(n=82).Patients in the combined group were treated with self-expanding stent-assisted coil embolization,and patients in the control group were treated with simple coil embolization.The aneurysm em-bolization effect,National Institute of Health stroke scale(NIHSS)score,activities of daily living(ADL)score,modified Rankin scale(mRS)score,surgical complications and recurrence rate of the two groups of patients were compared.Results Immediately after treatment,the propor-tion of patients with Raymond grade Ⅰ,Ⅱ,Ⅲ in the combined group was 58.16%,32.56%,and 9.18%,respectively.The proportion of pa-tients with grade Ⅰ,Ⅱ,Ⅲ in the control group was 40.24%,43.90%,and 15.85%,respectively.The embolization effect of the combined group was better than that of the control group,and the difference was statistically significant(P<0.05).At 1 and 3 months after treatment,the NIHSS scores of the combined group were(16.20±2.89)and(11.08±1.77)points,respectively,which were lower than those of the control group[(18.18±3.14)and(11.77±2.14)points],and the ADL scores were(71.3±5.8)and(78.9±6.4)points,respectively,which were higher than those of the control group[(68.4±6.6)and(74.7±7.0)points],the differences were statistically significant(P<0.05).There was no significant difference in the incidence of complications between the combined group and the control group(4.08%vs.3.66%)(P>0.05).After 3 months of treatment,neurological function recovery was evaluated according to the mRS grading standard.Overall,the neu-rological function prognosis recovery of the combined group was better than that of the control group,and the difference was statistically significant(P<0.05).The patients were followed up for 24 months,and the recurrence rate of the combined group was 8.16%,which was lower than that of the control group(18.29%).The difference was statistically significant(P<0.05).The time of no recurrence in the combined group was longer than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Self expanding stent assisted spring coil embolization is more effective in embolization of large or giant intracranial aneurysms than simple spring coil embolization,with better postoperative neurological function recovery and reduced long-term recurrence rate.