Evaluation value of programmed cell death ligand 1 expression on circulating tumor cells for prognosis of cervical cancer after concur-rent chemoradiotherapy
Evaluation value of programmed cell death ligand 1 expression on circulating tumor cells for prognosis of cervical cancer after concur-rent chemoradiotherapy
Objective To evaluate the expression of programmed cell death ligand 1(PD-L1)in circulating tumor cell(CTC)in the prognosis of cervical cancer after concurrent chemoradiotherapy.Methods Sixty patients with cervical cancer admitted to Linfen Peoples Hospital from June 2021 to December 2023 were retrospectively selected.All of them were confirmed by pathology,and CTC PD-L1 was determined by CytoSorter® CTC system.The correlation between pathological features of cervical cancer and PD-L1+CTC was analyzed,and the progression-free survival(PFS)of cervical cancer patients with PD-L1+CTC and PD-L1-CTC before and after concurrent chemoradiotherapy was com-pared,the prognostic value of PD-L1+CTC quantity before and after concurrent chemoradiotherapy of cervical cancer was evaluated.Results There were no statistically significant differences in the detection rate and quantity of peripheral blood CTC before and after synchronous radiothera-py and chemotherapy(P＞0.05).Compared with before synchronous radiotherapy and chemotherapy,the detection rate of PD-L1+CTC in cer-vical cancer patients after synchronous radiotherapy and chemotherapy was lower(38.33％vs.56.67％),and the number of PD-L1+CTC de-tected was lower[(0.77±1.20)vs.(1.27±1.51)],the differences were statistically significant(P＜0.05).Before concurrent chemoradio-therapy,PD-L1+CTC in patients with cervical cancer was closely related to tumor diameter,FIGO stage,differentiation degree and lymph node metastasis(P＜0.05).After concurrent chemoradiotherapy,the expression level of PD-L1+CTC in patients with cervical cancer was closely related to tumor diameter,FIGO stage,differentiation degree and lymph node metastasis(P＜0.05).The PFS of PD-L1+CTC patients was shorter than that of PD-L1-CTC patients,and the difference was significant(P＜0.05).Cox regression analysis showed that the expression level of CTC PD-L1 before and after concurrent radiotherapy and chemotherapy could be used as a prognostic factor for PFS in patients with local-ly advanced cervical cancer.Conclusion The expression level of CTC PD-L1 measured before and after radiotherapy and chemotherapy can be used as an auxiliary index for prognosis evaluation of cervical cancer.
关键词
宫颈肿瘤/同步放化疗/循环肿瘤细胞/细胞程序性死亡配体1/预后
Key words
Uterine cervical neoplasms/Concurrent chemoradiotherapy/Circulating tumor supracellular/Programmed cell death ligand 1/Prognosis
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