Objective To study the clinical characteristics and drug resistance profile of neonatal serratia marcescens infection/coloniza-tion.Methods The clinical characteristics and drug resistance profile of serratia marcescens culture positive neonates in neonatal ward of Beijing Friendship Hospital,Capital Medical University from January 2013 to December 2022 were retrospectively analyzed.Results A total of 17 neo-nates were included in this study,including 5 females and 12 males.The gestational age was(37.7±3.2)weeks and the birth weight was(3 067±794)g.There were 3 premature infants and 2 low birth weight infants.The positive specimens included umbilical secretions(8 cases,neonatal omphalitis),sputum(9 cases,including 6 cases of colonization and 3 cases of neonatal pneumonia),and blood(1 case,with sputum also posi-tive).Of the 17 cases,11 were community-derived,including 7 cases of omphalitis,3 cases of respiratory colonization,and 1 case of neonatal pneumonia.Serratia marcescens isolates in this study were resistant to amoxicillin and the first and second generation cephalosporin,and sensitive to the third generation cephalosporin,amicacin,ertabenem,levofloxacin,etc.Conclusion Serratia marcescens is not only one of the main pathogens of nosocomial infection in neonatal ward,but also leads to community infection or colonization.Clinical medical staff should strengthen the understanding of serratia marcescens,and regularly and systematically monitor the colonized bacteria in neonatal ward.
维普
万方数据