摘要
目的 维持性血液透析患者代谢性骨病发生情况及相关影响因素分析.方法 回顾性选择2022年2月至2024年5月在中山大学附属第五医院接受维持性血液透析患者277例为研究对象,以描述性分析方法分析代谢性骨病发生情况,并采用单因素、Logistic回归分析方法探究相关影响代谢性骨病发生的因素.结果 代谢性骨病检出率为51.62％.经单因素分析,性别、年龄、体重指数、运动习惯、透析时间、骨痛史、营养状况、25羟维生素D状况、合并基础疾病、合并骨质疏松症、合并肌少症、肝功能异常、钙磷代谢异常是手术患者发生代谢性骨病相关影响因素,差异均有统计学意义(P＜0.05).经Logistic回归分析显示,年龄(30～60岁,OR=7.985;＞60岁,OR=8.566)、体重指数(OR=2.688)、运动习惯(OR=5.096)、透析时间(OR=6.928)、合并基础疾病(OR=4.172)、营养状态(OR=2.766)、25羟维生素D状况(OR=3.823)、合并骨质疏松症(OR=5.511)、合并肌少症(OR=4.364)、肝功能异常(OR=5.825)、钙磷代谢异常(OR=5.825)均为引发代谢性骨病的危险因素(P＜0.05).结论 年龄、运动习惯、透析时间、合并基础疾病、营养状态、25羟维生素D状况、合并骨质疏松症、肌少症、肝功能异常以及钙磷代谢异常均是引发代谢性骨病的危险因素,需做好积极防护举措.
Abstract
Objective To analyze the incidence and related influencing factors of metabolic bone disease in maintenance hemodialysis pa-tients.Methods A total of 277 patients who underwent maintenance hemodialysis in the Fifth National Sun Yat-sen University Hospital from February 2022 to May 2024 were selected as the research subjects.Descriptive analysis was used to analyze the incidence of metabolic bone dis-ease,and single factor and logistic regression analysis were used to explore the relevant influencing factors.Results The detection rate of meta-bolic bone disease was 51.62％.Univariate analysis showed that gender,age,body mass index,exercise habits,dialysis time,history of bone pain,nutritional status,25 hydroxyvitamin D status,comorbidities with underlying diseases,comorbidities with osteoporosis,comorbidities with sarcopenia,abnormal liver function,and abnormal calcium and phosphorus metabolism were factors related to the occurrence of metabolic bone dis-ease,and the differences were statistically significant(P＜0.05).Logistic regression analysis showed that age(30-60 years old,OR=7.985;＞60 years old,OR=8.566),body mass index(OR=2.688),exercise habits(OR=5.096),dialysis time(OR=6.928),comorbidities with underlying diseases(OR=4.172),nutritional status(OR=2.766),25 hydroxyvitamin D status(OR=3.823),comorbidities with os-teoporosis(OR=5.511),comorbidities with sarcopenia(OR=4.364),liver dysfunction(OR=5.825),and abnormal calcium and phos-phorus metabolism(OR=5.825)were risk factors associated with metabolic bone disease(P＜0.05).Conclusion Age,exercise habits,di-alysis time,comorbidities,nutritional status,25 hydroxyvitamin D status,comorbidities with osteoporosis,sarcopenia,abnormal liver function,and abnormal calcium and phosphorus metabolism are all risk factors for metabolic bone disease,and active protective measures should be taken.
基金项目
广东省自然科学基金-面上项目(2021A1515010728)
NETL
NSTL
万方数据