小儿癫痫脑电图频段功率、放电指数和血乳酸水平变化及其与认知功能的关系
Changes in electroencephalography frequency band power,discharge index and blood lactate levels in pediatric epilepsy and their rela-tionship with cognitive function
潘高珍 1吴丹枫1
作者信息
- 1. 池州市人民医院神经电生理室 安徽 池州 247100
- 折叠
摘要
目的 探究小儿癫痫脑电图频段功率、放电指数、血乳酸水平变化情况,并探究其与患儿认知功能的关系.方法 回顾性选取2021年2月至2023年2月在池州市人民医院进行诊疗的小儿癫痫患儿病历资料进行统计,采用韦氏儿童智力量表(WISC-Ⅳ)评分对患儿的智力状况进行评估,抽取35例评分低于90分的癫痫患儿纳入研究组.另按照1∶1的比例,抽取35例智力正常的癫痫患儿纳入对照组.对两组患儿的脑电图频段功率情况、放电指数情况、血乳酸水平及认知功能情况进行监测,探究其相关性.结果 两组间在α频段、β频段、δ频段功率情况比较,差异均无统计学意义(P＞0.05),研究组θ频段功率为(21.39±2.12)Hz,高于对照组[(17.44±2.98)Hz],差异有统计学意义(P＜0.05).研究组在清醒期、睡眠期放电指数＞10％的患儿占比分别为17.14％、37.14％,均高于对照组(2.86％、5.71％),差异均有统计学意义(P＜0.05).研究组血乳酸水平为(8.55±1.23)mmol/L,高于对照组[(4.22±1.23)mmol/L],差异有统计学意义(P＜0.05).研究组的言语、操作智商及总智商分别为(68.26±5.99)、(79.15±5.46)、(75.26±6.88)分,均低于对照组[(88.12±6.45)、(95.28±5.89)、(91.11±6.15)分],差异均有统计学意义(P＜0.05).研究组患儿的θ频段功率、睡眠期放电指数、血乳酸与言语智商、操作智商、总智商均呈负相关(P＜0.05);清醒期放电指数与言语智商呈负相关(P＜0.05),但清醒期放电指数与操作智商、总智商无明显相关性(P＞0.05).结论 在小儿癫痫患者中,θ频段的功率、放电指数和血乳酸水平与认知功能下降有关,临床需密切关注其变化.
Abstract
Objective To explore the changes of frequency band power,discharge index and blood lactate level in electroencephalography in pediatric epilepsy,and to explore the relationship with the cognitive function of patients.Methods The medical records of children with epi-lepsy who were diagnosed and treated in Chizhou People's Hospital from February 2021 to February 2023 were retrospectively selected for statistics.The Wechsler intelligence scale for children(WISC-Ⅳ)score was used to evaluate the intelligence status of the children.Thirty-five children with epilepsy with a score below 90 were included in the study group.In addition,35 children with epilepsy with normal intelligence were selected as the control group according to the ratio of 1∶1.The electroencephalography band power,discharge index,blood lactate level and cognitive function of the two groups were monitored to explore the correlation.Results There was no statistically significant difference in the power of αband,β band and 8 band between the two groups(P＞0.05);the power of θ band in the study group was(21.39±2.12)Hz,which was high-er than that in the control group[(17.44±2.98)Hz],and the difference was statistically significant(P＜0.05).The proportions of children with a discharge index＞10％during the awake and sleep periods were 17.14％,37.14％,which were higher than those of the control group(2.86％,5.71％),the differences were statistically significant(P＜0.05).The blood lactic acid level of the study group was(8.55±1.23)mmol/L,which was higher than that of the control group[(4.22±1.23)mmol/L],and the difference was statistically significant(P＜0.05).The verbal IQ,operational IQ and total IQ of the study group were(68.26±5.99),(79.15±5.46)and(75.26±6.88)points,respectively,which were lower than those of the control group[(88.12±6.45),(95.28±5.89)and(91.11±6.15)points],and the differences were sta-tistically significant(P＜0.05).The θ-band power,sleep discharge index and blood lactic acid in the study group were negatively correlated with verbal IQ,operational IQ,and total IQ(P＜0.05).There was a negative correlation between discharge index and verbal IQ(P＜0.05),but there was no significant correlation between discharge index and operational IQ and total IQ(P＞0.05).Conclusion θ frequency,dis-charge index and blood lactate level are related to cognitive decline,with close attention in clinical practice.
关键词
小儿癫痫/脑电图/频段功率/放电指数/血乳酸/认知功能Key words
Pediatric epilepsy/Electroencephalography/Frequency band power/Discharge index/Blood lactic acid/Cognitive function引用本文复制引用
基金项目
安徽省高校自然科学研究重点项目(2022AH050678)
出版年
2024
NETL
NSTL
万方数据