多索茶碱片、噻托溴铵联合肺康复训练治疗肺尘埃沉着病患者的临床疗效
Effect of doxofylline tablets,tiotropium bromide combination with pulmonary rehabilitation training in the treatment of pneumoconio-sis
敖湘 1杜冬峰 2白晓旭 3杨哲 1王亚辉 2孟晓东2
作者信息
- 1. 北京中医药大学房山医院康复科 北京 102400
- 2. 北京中医药大学房山医院疼痛科 北京 102400
- 3. 北京中医药大学房山医院科教科 北京 102400
- 折叠
摘要
目的 探究多索茶碱片、噻托溴铵联合肺康复训练(PRT)治疗肺尘埃沉着病患者的临床疗效.方法 将2021年5月至2022年12月北京中医药大学房山医院收治的100例肺尘埃沉着病患者纳入本次前瞻性研究,按照随机数字表法将其分为对照组(n=50)和研究组(n=50).对照组接受多索茶碱片+噻托溴铵治疗,研究组接受多索茶碱片+噻托溴铵+PRT治疗,治疗时间为8周.比较两组的临床疗效,治疗前及治疗2、4和8周后的肺功能指标[第一秒用力肺活量(FEV1)、FEV1占用力肺活量(FVC)的比率(FEV1/FVC)和最大通气量(MVV)]、Borg呼吸困难评分、6 min步行训练(6MWT)和生活质量评分[圣乔治呼吸问卷(SGRQ)].结果 研究组的总有效率为96.00％,显著高于对照组(84.00％),差异有统计学意义(P＜0.05).治疗2、4和8周后,两组的FEV1、FEV1/FVC和MVV均较治疗前显著升高,且研究组治疗2、4和8周后的FEV1、FEV1/FVC和MVV均显著高于对照组,差异均有统计学意义(P＜0.05).治疗2、4和8周后,两组的Borg评分、SGRQ评分均较治疗前降低,而6MWT均较治疗前升高,且研究组治疗2、4和8周后的Borg评分、SGRQ评分均显著低于对照组,而6MWT均显著高于对照组,差异均有统计学意义(P＜0.05).结论 多索茶碱片、噻托溴铵联合PRT治疗肺尘埃沉着病患者的临床疗效显著,可显著改善患者的肺功能和生活质量,提高运动耐量.
Abstract
Objective To investigate the clinical effect of doxofylline tablets,tiotropium bromide combination with pulmonary rehabilita-tion training(PRT)in the treatment of pneumoconiosis.Methods A total of 100 pneumoconiosis patients admitted to Fangshan Hospital of Bei-jing University of Traditional Chinese Medicine from May 2021 to December 2022 were included in this prospective study.They were divided into the control group(n=50)and the study group(n=50)according to the random number table method.The control group received doxorubicin tablets+tiotropium bromide treatment,while the study group received doxorubicin tablets+tiotropium bromide+PRT for 8 weeks.The clinical ef-ficacy,ulmonary function indicators[forced expiratory volume in 1 second(FEV1),FEV1/forced vital capacity(FVC),and maximal ventilation(MVV)],Borg dyspnea score,6-minute walking test(6MWT),quality of life score(SGRQ),and before treatment and after 2,4 and 8 weeks of treatment were compared.Results The total effective rate of the study group was 96.00％,which was significantly higher than that of the con-trol group(84.00％),and the difference was statistically significant(P＜0.05).After 2,4 and 8 weeks of treatment,the FEV1,FEV1/FVC and MVV of the two groups were significantly higher than those before treatment,and the FEV1,FEV1/FVC and MVV of the study group after 2,4 and 8 weeks of treatment were significantly higher than those of the control group,the differences were statistically significant(P＜0.05).Af-ter 2,4 and 8 weeks of treatment,the Borg score and SGRQ score of the two groups were lower than those before treatment,while the 6 MWT was higher than that before treatment,and the Borg score and SGRQ score of the study group after 2,4 and 8 weeks of treatment were significantly low-er than those of the control group,while the 6 MWT was significantly higher than that of the control group,the differences were statistically signifi-cant(P＜0.05).Conclusion The combination of doxorubicin tablets,tiotropium bromide with PRT in the treatment of pneumoconiosis patients has better clinical efficacy,it can significantly improve their pulmonary function and quality of life,and enhance exercise tolerance.
关键词
多索茶碱片/噻托溴铵/肺康复训练/尘肺/肺功能Key words
Doxophylline tablets/Tiotropium bromide,Pulmonary rehabilitation training,Pneumoconiosis/Pulmonary function引用本文复制引用
出版年
2024
NETL
NSTL
万方数据