血清ALP、HE4联合SII指数与卵巢癌肿瘤良恶性程度相关性及预后影响因素分析
Correlation analysis of serum ALP,HE4 combined SII index with benign and malignant degree of ovarian cancer and prognostic fac-tors
岳红 1汤进 1陈钢1
作者信息
- 1. 汉中市中心医院妇科 陕西 汉中 723000;汉中市中心医院检验科 陕西 汉中 723000
- 折叠
摘要
目的 分析血清碱性磷酸酶(ALP)、附睾分泌蛋白4(HE4)联合全身免疫炎症(SII)指数与卵巢癌肿瘤良恶性程度相关性及预后影响因素.方法 回顾性选择自2020年6月至2023年4月汉中市中心医院收治的80例卵巢癌患者作为观察组,另选同期的80例卵巢良性肿瘤患者作为对照组.检测所有患者血清ALP、HE4表达水平,计算SII指数.比较观察组与对照组血清ALP、HE4表达水平及SII指数,分析血清ALP、HE4表达水平及SII指数与卵巢癌患者病理分期、分化程度及淋巴结转移的关系,使用COX回归分析法分析卵巢癌预后的影响因素.结果 观察组的血清ALP、HE4 表达水平分别为(156.23±38.74)U/L、(308.36±45.24)pmol/L,均高于对照组[(86.92±10.45)U/L、(50.23±12.47)pmol/L],SII 指数为 548.93±70.95,大于对照组(352.12±46.84),差异均有统计学意义(P＜0.05).随着卵巢癌患者病理分期增大和分化程度减小,其血清ALP、HE4表达水平呈升高趋势,SII指数呈增大趋势,血清ALP、HE4表达水平和SII指数在不同病理分期和分化程度的卵巢癌患者中差异均有统计学意义(P＜0.05).经Spearmen相关性分析,卵巢癌患者血清ALP、HE4表达水平和SII指数与病理分期呈正相关(P＜0.05),与分化程度呈负相关(P＜0.05).经ROC曲线分析,血清ALP、HE4联合SII指数预测卵巢癌患者淋巴结转移的敏感度为89.76％,特异度为60.37％,AUC为0.923.在80例卵巢癌患者中,术后随访12个月,发生复发转移15例,占18.75％.经COX回归分析,病理分期、分化程度、ALP、HE4、SII指数均是卵巢癌患者复发转移的独立影响因素(P＜0.05).结论 卵巢癌患者血清ALP、HE4表达明显上调和SII指数明显增大,与其肿瘤恶性程度密切相关,对其预后具有一定影响,值得临床予以重视应用.
Abstract
Objective To analyze the correlation between serum alkaline phosphatase(ALP),human epididymis secretory protein 4(HE4)and systemic immunoinflammatory(SII)index with benign and malignant degree of ovarian cancer and the prognostic factors.Methods A total of 80 patients with ovarian cancer admitted to Hanzhong Central Hospital from June 2020 to April 2023 were retrospectively selected as the observation group,another 80 patients with benign ovarian tumors in the same period were selected as the control group.The expression levels of serum ALP and HE4 in all patients were detected,and the SII index was calculated.The expression levels of serum ALP,HE4 and SII index were compared between the observation group and the control group.The relationship between the expression levels of serum ALP,HE4 and SII index and the pathological stage,differentiation degree and lymph node metastasis of ovarian cancer patients was analyzed.The prognostic factors of ovar-ian cancer were analyzed using by COX regression analysis.Results The expression levels of serum ALP and HE4 in the observation group were(156.23±38.74)U/L and(308.36±45.24)pmol/L,respectively,which were higher than those in the control group[(86.92±10.45)U/L,(50.23±12.47)pmol/L],the SII index was 548.93±70.95,which was higher than that in the control group(352.12±46.84),and the differences were statistically significant(P＜0.05).And differentiation degree decreases with increase in patients with ovarian cancer pathologi-cal staging,the serum ALP,HE4 expression levels showed a trend of increase,SII index showed a trend of increase and serum ALP,HE4 expres-sion level and SII index in different pathological staging and differentiation in ovarian cancer patients were significant difference(P＜0.05).By Spearmen correlation analysis,the ovarian cancer patients serum ALP,HE4 expression level and SII index was positively related with pathological staging(P＜0.05),and negatively correlated with degree of differentiation(P＜0.05).ROC curve analysis showed that the sensitivity,speci-ficity and AUC of serum ALP,HE4 combined with SII index to predict lymph node metastasis in ovarian cancer patients were 89.76％,60.37％and 0.923.In the 80 cases of ovarian cancer patients,15 cases(18.75％)had recurrence and metastasis after 12 months of follow-up.By COX regression analysis,pathologic stage,differentiation,ALP,HE4,SII index were independent factors affecting recurrence of ovarian cancer metas-tasis(P＜0.05).Conclusion Serum ALP,HE4 expression and SII index of ovarian cancer patients are significantly up-regulated,which is closely related to the degree of malignancy of the tumor,and has a certain influence on the prognosis,which is worthy of clinical application.
关键词
卵巢癌/碱性磷酸酶/人附睾分泌蛋白4/全身免疫炎症指数Key words
Ovarian cancer/Alkaline phosphatase/Human epididymis secretory protein 4/Systemic immune inflammatory index引用本文复制引用
出版年
2024
NETL
NSTL
万方数据