Objective This study aims to compare the efficacy and safety of generating nitric oxide complex solution combined with mi-croneedles on female pattern hair loss(FPHL)patients.Methods A total of 60 FPHL patients with Sinclair Ⅱ and Ⅲ menstrual regularity re-cruited from the dermatology clinic of Beijing Friendship Hospital,Capital Medical University from November 2023 to February 2024 were prospec-tively studied.According to the random number table method,the patients were divided into the experimental group and the control group,with 30 cases in each group.The experimental group was treated with microneedle combined with nitric oxide source complex solution,nitric oxide source complex solution 1 time/week,a total of 5 times,followed by 1 time/2 weeks,a total of 5 times,a total of 14 weeks;the control group was treated with minoxidil tincture,1 Ml of 5％minoxidil tincture was applied once a day for 14 weeks.Hair growth(hair density and hair shaft diameter un-der dermatoscope)in intra-group and intergroup,physician evaluation(Sinclair's scores and 7-point global-assessment scale),patient evalua-tion(the women's androgenetic alopecia quality of life questionnaire and patients'satisfaction)and the adverse effects were compared at 16 weeks of treatment.Results At 16 weeks of treatment,the hair density and hair diameter of the two groups were significantly improved compared with those before treatment,and the differences were statistically significant(P＜0.05).At 16 weeks of treatment,there was no statistically signifi-cant difference in the mean values of hair density and hair diameter between the two groups(P＞0.05).At 16 weeks of treatment,the effective rate was 50.0％in the experimental group and 43.3％in the control group,and the difference was not statistically significant(P＞0.05).At 16 weeks of treatment,the WAA-QOL scores of the two groups were significantly higher than those before treatment.The WAA-QOL score of the experimental group was 72(68,80)points,which was higher than that of the control group[57(50,67)points],and the differences were statistically significant(P＜0.05).The overall satisfaction rate of the experimental group was 86.7％,which was significantly higher than that of the control group(76.7％),and the difference was statistically significant(P＜0.05).The incidence of adverse reactions in the experimental group was 13.3％,which was significantly lower than that in the control group(73.3％),the difference was statistically significant(P＜0.05).Conclusion There is no difference between the efficacy of microneedle combined with nitric oxide source complex solution and the external appli-cation of minoxidil solution in the treatment of female pattern hair loss,and it can effectively promote hair growth.Besides,microneedle combined with nitric oxide source complex solution has less adverse reactions and better safety than the external application of minoxidil solution.
维普
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