Objective To observe the effects of local microwave ablation combined with immunotherapy on serum cytokeratin-19 frag-ment(CYFRA21-1),vascular endothelial growth factor(VEGF),helper T cell 1(Th1)and helper T cell 2(Th2)in patients with lung canc-er.Methods A total of 84 patients with NSCLC admitted to Cangzhou People's Hospital from January 2020 to January 2023 were prospectively se-lected as the study subjects.According to the random number table method,they were divided into the observation group and the control group,with 42 cases in each group.The control group was treated with gemcitabine combined with cisplatin(GP regimen),and the observation group was treated with local microwave ablation combined with pabolizumab.The clinical effect of the two groups was compared.Serum levels of CYFRA21-1,VEGF,Th1 and Th2 were detected.The incidence of adverse reactions was compared between the two groups.Follow-up for 1 year,the survival and recurrence of the two groups were observed.Results The total effective rate of the observation group was 80.95％,which was higher than that of the control group(59.52％),and the difference was statistically significant(P＜0.05).After 2 cycles of treatment,the levels of CYFRA21-1 and VEGF in the two groups were lower than those before treatment,and the levels of CYFRA21-1 and VEGF in the observation group were(3.62±0.59)μg/L and(251.12±61.63)μg/mL,respectively,which were lower than those in the control group[(4.47±0.81)μg/L,(386.37±84.59)μg/mL],the differences were statistically significant(P＜0.05).After 2 cycles of treatment,the levels of Th1,Th2 and Th1/Th2 in the two groups were lower than those before treatment,and the levels of Th1,Th2 and Th1/Th2 in the observation group were(1.95±0.41)％,(1.75±0.49)％and 1.25±0.28,respectively,which were lower than those in the control group[(3.81±0.58)％,(2.48±0.63)％and 1.49±0.42],the differences were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).There was no statistically significant difference in 1-year recurrence rate between the two groups(P＞0.05).The 1-year survival rate of the observation group was 88.10％,which was higher than that of the con-trol group(69.05％),and the difference was statistically significant(P＜0.05).Conclusion Compared with GP chemotherapy,local micro-wave ablation combined with immunotherapy for patients with NSCLC is beneficial to improve clinical efficacy,and has better effects in inhibiting serum tumor markers and improving immune function,which is conducive to improving the 1-year survival rate of patients.
关键词
肺癌/局部微波消融/免疫检查点抑制剂/肿瘤标志物/免疫功能
Key words
Lung cancer/Local microwave ablation/Immune checkpoint inhibitors/Tumor markers/Immune function
维普
万方数据