Diagnostic value of gastric-filling contrast-enhanced ultrasonography combined with serum miRNA-210 in the diagnosis of reflux esophagitis in elderly people
Diagnostic value of gastric-filling contrast-enhanced ultrasonography combined with serum miRNA-210 in the diagnosis of reflux esophagitis in elderly people
Objective To investigate the diagnostic predictive value of gastric-filling contrast-enhanced ultrasonography combined with serum microRNA(miRNA)-210 in the diagnosis of reflux esophagitis(RE)in the elderly population.Methods This study retrospectively in-cluded 140 elderly patients with suspected gastroesophageal reflux disease(GERD)who visited Hebei Petro China Central Hospital between Octo-ber 2023 and March 2024 as study subjects.According to the occurrence of RE,they were divided into RE group(n=90)and non-RE group(n=50).Gastric-filling contrast-enhanced ultrasonography by the filling method was performed on all study subjects,and ultrasonographic sonograms,ultrasonic anatomical structural features such as His angle and length of the abdominal segmental esophagus were recorded.Real-time quantitative fluorescence-polymerase chain reaction(RT-qPCR)assay was detected using serum miRNA-210 expression levels in GERD pa-tients.The diagnostic value of serum miRNA-210,His angle,abdominal segmental esophagus length and the combination for RE in the elderly was analyzed using the subject's work characteristics(ROC)curve.Results The His angle of the RE group was(67.77±7.11)°,which was greater than that of the non-RE group[(53.95±5.12)°],and the length of the abdominal esophagus was(2.47±0.85)cm,which was smaller than that of the non-RE group[(3.56±0.78)cm],the differences were statistically significant(P＜0.05).The serum miRNA-210 level in the RE group was 5.17±1.55,which was significantly higher than that in the non-RE group(2.58±0.96),and the difference was statistically significant(P＜0.05).The ROC curve analysis results showed that the area under the curve(AUC)of gastric filling ultrasonography parameters(His angle,abdominal segmental esophageal length),serum miRNA-210 and the combination of the three on the occurrence of RE in patients were 0.830,0.955,0.938,0.995;the results of AUC comparison showed that the combined prediction was superior to the individual pre-diction(P＜0.05).Conclusion Gastric-filling contrast-enhanced ultrasonography and serum miRNA-210 levels have high diagnostic value for RE in the elderly,and the combination has the highest diagnostic value.
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