Objective To analyze the results and clinical diagnostic value of serum B cell specific moloney leukemia virus insertion site 1(Bmi-1)combined human papilloma virus(HPV)-DNA typing in patients with cervical cancer.Methods A total of 80 patients with cervical cancer who visited Daqing Longnan Hospital from January 2022 to June 2024 were retrospectively included as the study objects and set as the obser-vation group.The observation group was subdivided into the malignant group(n=36)and the benign group(n=44)based on the results of surgical and pathological tests as the gold standard.At the same time,40 women who went to our hospital for physical examination in the same pe-riod were selected as the control group.All patients received serum Bmi-1 and HPV-DNA typing tests,and the serum Bmi-1 and HPV-DNA typing test results of each group,as well as the relationship between positive expression of the two and clinicopathological parameters,and the diag-nostic value of single detection and combined detection were compared and analyzed.Results The serum Bmi-1 expression and HPV-DNA typing test results of the three groups were compared,and the differences were statistically significant(P＜0.05).Among them,the serum Bmi-1 expression and HPV-DNA total positive rate in the malignant group were 0.42±0.12 and 91.67％,respectively,which were significantly higher than those in the benign group(0.29±0.08,27.27％)and the control group(0.21±0.07,7.50％),and the differences were statisti-cally significant(P＜0.05).Spearman correlation analysis showed that serum Bmi-1 expression was positively correlated with HPV-DNA typ-ing results(r=0.492,P＜0.05).With surgical pathologic detection as the gold standard,the accuracy,sensitivity and specificity of serum Bmi-1 and HPV-DNA typing were higher than that of single detection in the diagnosis of cervical cancer,and the differences were statistically signif-icant(P＜0.05).Serum Bmi-1 expression was correlated with clinical stage and lymph node metastasis of cervical cancer(P＜0.05),but not with age or pathological classification(P＞0.05).HPV-DNA typing was not correlated with age,pathological classification,clinical stage or lymph node metastasis(P＞0.05).Conclusion The expression of serum Bmi-1 is up-regulated in patients with cervical cancer,and HPV-DNA typing is dominated by high-risk types such as 16 and 18.Serum Bmi-1 is positively correlated with HPV-DNA typing results,which may play a synergistic role in the occurrence and progression of cervical cancer,and the combination of the two methods is effective in the diagnosis of cervical cancer.
维普
万方数据