Clinical study on the treatment of recurrent moderate-to-severe plaque-type psoriasis with a combination of comfreyin and detox-ification,stasis-resolving and collateral-passing formulae
Clinical study on the treatment of recurrent moderate-to-severe plaque-type psoriasis with a combination of comfreyin and detox-ification,stasis-resolving and collateral-passing formulae
Objective To observe the clinical effect of ziziphusin combined with detoxification,resolving blood stasis and circulation for-mula in the treatment of recurrent moderate-to-severe plaque-type psoriasis.Methods A total of 116 patients with recurrent moderate to se-vere plaque psoriasis admitted to the Department of Dermatology,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from May 2021 to December 2023 were prospectively selected and divided into the Western medicine group and the Chinese-Western medicine combi-nation group according to the simple random method,with 58 cases in each group.The Western medicine group was treated with ustekinumab.The Chinese-Western medicine combination group was treated with ustekinumab combined with licorice and a decoction that promotes blood circula-tion and removes stasis,on the basis of the Western medicine group.The Chinese medicine syndrome scores,body surface affected area,dermatol-ogy life quality index(DLQI)score,skin physiological barrier function,psoriasis area and severity index(PASI)score,macrophage colony stim-ulating factor(M-CSF),monocyte chemoattractant protein-1(MCP-1),and CD4+T lymphocyte subset differences were compared before and after 8 weeks of treatment between the two groups.The occurrence of adverse reactions in the two groups was recorded.Results After 8 weeks of treatment,the scores of chinese medicine syndromes in the two groups were lower than those before treatment,and the scores of chinese medicine syndromes in the Chinese-Western medicine combination group were lower than those in the western medicine group,the differences were statistically significant(P＜0.05).After 8 weeks of treatment,the DLQI score,PASI score and body surface affected area of the two groups were lower than those before treatment,and the DLQI score,PASI score and body surface affected area of the Chinese-Western medicine combi-nation group were lower than those of the Western medicine group,the differences were statistically significant(P＜0.05).After 8 weeks of treatment,the stratum corneum water content and sebum content of the two groups were higher than those before treatment,and the transepidermal water loss was lower than that before treatment.The stratum corneum water content and sebum content of the Chinese-Western medicine combina-tion group were lower than those of the Western medicine group,and the transepidermal water loss was lower than that of the control group,the differences were statistically significant(P＜0.05).After 8 weeks of treatment,the levels of MCP-1 and M-CSF in the two groups were lower than those before treatment,and the levels of MCP-1 and M-CSF in the Chinese-Western medicine combination group were lower than those in the Western medicine group,the differences were statistically significant(P＜0.05).After 8 weeks of treatment,Th1 and Th 17 in the two groups were lower than those before treatment,Th2 and Treg were higher than those before treatment,and Th1 and Th17 in the Chinese-Western medicine combination group were lower than those in the Western medicine group,Th2 and Treg were lower than those in the Western medicine group,the differences were statistically significant(P＜0.05).There was no statistically significant difference in the incidence of adverse reac-tions between the two groups(P＞0.05).Conclusion The treatment of recurrent moderate-to-severe plaque psoriasis with comedones com-bined with a detoxifying,stasis-resolving,and collateral-promoting formula down-regulates the inflammatory response immune response,re-duces symptoms,and improves the physiological barrier function of the skin.
关键词
银屑病/紫草素/解毒化瘀通络方/复发性/皮肤生理屏障功能
Key words
Psoriasis/Comfreyin/Detoxification/Elimination of blood stasis and circulation formula/Recurrent/Skin physiological bar-rier function
维普
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