以莰烯衍生物内型异莰烷基甲醛与氨基硫脲衍生物进行缩合反应，合成了5 种缩氨基硫脲类化合物(3a～3e)，并通过IR、MS、1 H NMR和13 C NMR等分析方法对其结构进行了表征。采用菌丝生长速率法测试了化合物3a～3e对水稻纹枯病菌等8 种植物病原菌的生长抑制作用，结果表明:5 种化合物中，内型异莰烷基甲醛缩氨基硫脲(3a)对8 种植物病原菌的抑制率最高，在质量浓度为50 mg/L时，3a对油茶炭疽病菌、枇杷炭疽病菌的抑制率分别为91。9%和97。2%，对油茶果生刺盘孢菌和彩绒革盖菌的抑制率均达100%，对水稻纹枯病菌、松枯梢病病原菌和西瓜枯萎病菌的抑制率分别为 80。7%、79。8%、79。5%，均优于阳性对照样百菌清。
Synthesis and Antifungal Activity of Endo-isocamphanyl-formaldehyole Thiosemicarbazides
5 endo-isocamphanyl-formaldehyole thiosemicarbazide compounds(3a-3e)were synthesized by condensation reactions of camphene derivatives endo-isocamphanyl-formaldehyole with thiosemicarbazide derivatives.Their structures were characterized by IR,MS,1 H NMR and 13 C NMR.The mycelial growth rate method was used to study the inhibition effects of the related compounds on the growth of 8 plant pathogenic fungi including Rhizoctonia solani.The results showed that,among 5 compounds,the inhibition rate of endo-isocamphanyl-formaldehyole thiosemicarbazide(3a)was the highest against 8 plant pathogenic fungi.At the mass concentration of 50 mg/L,the inhibition rates of 3a against Colletotrichum gloeosporioides and Colletotrichum acutatum were 91.9%and 97.2%,respectively.The inhibition rates of 3a against Colletotrichum fructicola and Coriolus versicolor were both 100%.The inhibition rates of 3a against Rhizoctonia solani,Sphaeropsis sapinea and Fusariumoxyporum f.sp.niveum were 80.7%,79.8%and 79.5%,respectively,which were better than that of the positive control sample of Chlorothalonil.
万方数据
维普
