首页|木质素及其衍生物在医药行业的应用研究进展

木质素及其衍生物在医药行业的应用研究进展

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木质素具有良好的生物相容性、化学稳定性和可加工性,在生物医学和组织工程领域展现出广泛的应用潜力。在简单介绍木质素结构的基础上,综述了木质素作为医药行业新型负载材料的研究进展,如药物载体及缓释系统、医用辅助材料和医学生物传感器等;介绍了木质素在抗病毒、抗肿瘤、调节血糖和血脂,以及抗炎、抗凝血和护肤等方面的药理学活性;总结了香草醛及其衍生物、邻苯二酚和苯酚等木质素降解产物的应用情况。最后分析了当前木质素及其衍生物在医药行业应用过程中存在的问题及未来的研究方向,旨在推动木质素从工业废弃物向高附加值医药应用的转型,以实现其在医药领域的更广泛应用。
Research Progress on the Application of Lignin and Its Derivatives in the Pharmaceutical Industry
Lignin had good biocompatibility,chemical stability,and processability,demonstrating a wide range of potential applications in biomedical and tissue engineering fields.On the basis of a brief introduction to the structure of lignin,this paper reviewed the research progress of lignin as a new type of loading material in the pharmaceutical industry,such as drug carriers and sustained-release systems,medical auxiliary materials,and pharmaceutical biosensors.The pharmacological activities of lignin in antiviral,anti-tumor,blood glucose and lipid regulation,as well as anti-inflammatory,anticoagulant,and skincare were introduced.The application of lignin degradation products such as vanillin and its derivatives,catechol and phenol were summerized.Finally,the problems and future directions in the application of lignin and its derivatives in the pharmaceutical industry were analyzed,aiming to promote the transformation of lignin from industrial waste to high value-added pharmaceutical applications,in order to achieve its wider application in the pharmaceutical field.

lignocelluloseligninmedical materialspharmacological activity

丘勇豪、谭雪松、高静静、庄新姝、孙悦

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广东药科大学中药学院,广东 广州 510006

中国科学院广州能源研究所

中国科学院可再生能源重点实验室

广东省新能源与可再生能源研究开发与应用重点实验室,广东 广州 510640

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木质纤维素 木质素 医用材料 药理活性

国家重点研发计划政府间国际科技创新合作重点专项国家自然科学基金资助项目广东省基础与应用基础研究基金资助项目

2021YFE0114400519762212022A1515012078

2024

林产化学与工业
中国林业科学研究院林产化学工业研究所 中国林学会林产化学化工分会

林产化学与工业

CSTPCD北大核心
影响因子:0.696
ISSN:0253-2417
年,卷(期):2024.44(5)