The correlation between the expression of insulin-like growth factor-1 and insulin-like growth factor binding protein-1 and cognitive impairment in first-episode schizophrenic patients
Objective:To investigate the relationship between the levels of serum insulin-like growth fac-tor-1(IGF-1)and insulin-like growth factor binding protein-1(IGFBP-1)and cognitive function in patients with schizophrenia.Method:The expression levels of serum IGF-1 and IGFBP-1 proteins in 103 patients with schizophrenia and 64 healthy controls(HCs)were detected using enzyme-linked immunosorbent assay(ELISA).The clinical symptoms and severity of patients were evaluated using the Positive and Negative Syn-drome Scale(PANSS).The cognitive function of the subjects was evaluated using the Chinese version of the Cognitive Function Battery(MCCB).Results:The expression of IGFBP-1 in peripheral blood of patients with schizophrenia increased(P =0.01),while the expression of IGF-1 showed no significant difference compared with the HCs group(P＞0.05).The expression level of IGF-1 was negatively correlated with the working mem-ory,verbal learning and memory,visual learning and memory,social cognition,and total score of MCCB in the cognitive function dimensions of patients(all P＜0.05),while the expression level of IGFBP-1 was negatively correlated with the processing speed score in the cognitive function dimensions of patients(P＜0.05).There was no correlation between the expression levels of IGF-1 and IGFBP-1 in the healthy controls and the cognitive function scores(P＞0.05).Conclusion:The expression of IGF-1 and IGFBP-1 in the serum of patients with schizophrenia is negatively correlated with the cognitive function of patients,indicating that this IGF-1/IGFBP-1 plays a certain role in the cognitive impairment of schizophrenia.
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