Comparative analysis of equivalent dose of antipsychotic drugs in schizophrenic patients of different sexes and ages
Objective:To explore the difference of equivalent dose of antipsychotic drugs in schizophren-ic patients of different sexes and ages.Method:1 552 inpatients with schizophrenia were retrospectively in-vestigated and analyzed.According to the antipsychotic drugs taken,the equivalent dose was converted,and the difference of equivalent dose of antipsychotic drugs in terms of gender and age was analyzed.Results:The re-sults of gender grouping showed that the effective dose of risperidone group,combination drug group,and clozap-ine group in female schizophrenic patients were(10.53±2.57)mg,(18.45±7.08)mg,and(6.54±2.58)mg,respectively,significantly lower than those in male schizophrenic patients(P＜0.01 or P＜0.05).The re-sults of age grouping showed that the effective dose of 55～66 years was the lowest,and the dosage of male pa-tients aged 16～55 years was significantly higher than that of female patients,with a statistically significant difference(P＜0.001 or P =0.001).Conclusion:Sex and age may influence the dosage of antipsychotic drugs in schizophrenic patients.
万方数据
维普
