首页|长期住院精神分裂症患者血糖影响因素的研究

长期住院精神分裂症患者血糖影响因素的研究

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目的:探讨住院精神分裂症患者影响血糖代谢相关因素.方法:收集2019 年1 月1 日至2021 年12 月31 日期间1 174 例住院精神分裂症患者的性别、年龄、受教育程度、病程、高血压病史、使用抗精神病药物等相关资料,以2021 年12 月空腹血糖值分为血糖正常组和血糖异常组,收集患者 2019年12 月和2021 年12 月空腹血糖、尿酸、三酰甘油、总胆固醇、高密度脂蛋白及低密度脂蛋白等相关指标并分析.结果:整体血糖异常组和血糖正常组2021 年血糖均高于2019 年(P<0.05),血糖异常组更显著(Z =-2.800,P<0.05).血糖异常组在年龄、病程、高血压患病率、氯氮平使用率、利培酮使用率、尿酸水平、三酰甘油水平均明显高于血糖正常组;血糖异常组在阿立哌唑使用率和高密度脂蛋白水平低于血糖正常组.三酰甘油水平、年龄、氯氮平、利培酮、高血压是 2021 年血糖的影响因素(P<0.05).结论:三酰甘油水平、年龄、氯氮平、利培酮、高血压是住院精神分裂症患者发生血糖异常或者糖尿病的危险因素.
Study on the influencing factors of blood glucose in long-term hospitalized patients with schizophrenia
Objective:To explore the related factors affecting blood glucose metabolism in inpatients with schizophrenia.Method:A total of 1 174 hospitalized patients with schizophrenia from January 1,2019 to De-cember 31,2021 were collected,including their gender,age,education level,course of illness,history of hyper-tension,and use of antipsychotic drugs.Divide into normal blood glucose group and abnormal blood glucose group based on the fasting blood glucose values in December 2021.Collect and analyze relevant indicators such as fasting blood glucose,uric acid,triglycerides,total cholesterol,high-density lipoprotein,and low-density lipo-protein from patients in December 2019 and December 2021.Results:The blood glucose in the whole group,abnormal blood glucose group and normal blood glucose group in 2021 was higher than that in 2019(P<0.05),especially in abnormal blood glucose group(Z =-2.800,P<0.05).The abnormal blood glucose group had significantly higher levels of age,disease course,prevalence of hypertension,use of clozapine,use of risperi-done,uric acid levels,and triglyceride levels than the normal blood glucose group;The use rate of Aripiprazole and the level of High-density lipoprotein in the abnormal blood glucose group were lower than those in the nor-mal blood glucose group.Triglyceride levels,age,clozapine,risperidone,and hypertension are the influencing factors of blood glucose in 2021(P<0.05).Conclusion:The level of triglyceride,age,clozapine,risperi-done and hypertension are the risk factors of abnormal blood glucose or diabetes in inpatients with schizophrenia.

schizophrenialong term hospitalizationblood glucoseinfluence factor

王培源、马志根、陈学红

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211800 南京市浦口人民医院

南京市佑安医院

精神分裂症 长期住院 血糖 影响因素

2021年度南京市卫生科技发展项目

YKK21236

2024

临床精神医学杂志
南京医科大学附属脑科医院

临床精神医学杂志

CSTPCD
影响因子:1.108
ISSN:1005-3220
年,卷(期):2024.34(1)
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