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非自杀性自伤的内分泌免疫研究进展

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非自杀性自伤(NSSI)多发生在青少年和成年早期,与情绪相关疾病发生率增高及发展至难治性等相关,是自杀的重要危险因素.NSSI人群其内分泌和免疫发生一些变化,探讨NSSI发生的内分泌免疫机制,可能有助于NSSI早期预防与干预.本文从下丘脑-垂体-肾上腺轴(HPA轴)、下丘脑-垂体-甲状腺轴(HPT轴)、下丘脑-垂体-性腺轴(HPG轴)及免疫炎症与NSSI发生的相关研究进展作一综述.
Research progress in endocrine-immune for non-suicidal self-injury
Non-suicidal self-injury(NSSI),being one of the most important suicide risk factors,mostly oc-cur in adolescent and early adulthood,which is related to the mood disorder and move forward to treatment re-sistant.People with NSSI have some changes in endocrine-immune.Exploring the mechanism on endocrine-im-mune for NSSI will help to earlier prevention and intervention.This article will review the research progress for NSSI on the following endocrine-immune aspects such as hypothalamic-pituitary-adrenal axis(HPA),hypotha-lamic-pituitary-thyroid axis(HPT),hypothalamic-pituitary-gonadal axis(HPG)and the immune inflammation.

non-suicidal self-injuryadolescent and early adulthoodhypothalamic-pituitary-adrenal axishypothalamic-pituitary-thyroid axishypothalamic-pituitary-gonadal axisimmune inflammation

周洛慧、苏颖芮、柳绪珍、孙静

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210029 南京医科大学

南京医科大学附属脑科医院

非自杀性自伤 青少年及成年早期 下丘脑-垂体-肾上腺轴 下丘脑-垂体-甲状腺轴 下丘脑-垂体-性腺轴 免疫炎症

南京市卫生科技发展项目

YKK22141

2024

10.3969/j.issn.1005-3220.2024.01.022

临床精神医学杂志
南京医科大学附属脑科医院

临床精神医学杂志

CSTPCD
影响因子：1.108
ISSN：1005-3220
年,卷(期)：2024.34(1)
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