Clinical observation of sertraline combined with rational emotion therapy for patients with primary ado-lescent depression
Objective:To explore the clinical efficacy and safety of sertraline combined with rational e-motion therapy for adolescent patients with first-episode depression.Method:A total of 90 adolescent patients with first-episode depression who attended the sleep and psychological clinic of the First Hospital of Wuhan from April 2020 to April 2022 were selected and randomly divided into the research group and the control group,45 patients in each group.Patients of the research group were given sertraline combined with rational emotion thera-py,patients of the control group were given sertraline.The Hamilton Depression Scale(HAMD)and symptom Self-evaluation Scale(SCL-90)were used to assess the emotional status before and at the end of the 4th and 8th week after treatment,while the safety of drugs was assessed using Treatment Emergent Symptom Scale(TESS).Results:Total HAMD scores and the score of anxiety/somatization、cognitive impairment、block、systemic symp-toms decreased at the end of the 4th and 8th week after treatment compared with those before treatment(all P＜0.05),while total HAMD gross score and the score of cognitive impairment and block of the study group were lower than that of the control group(all P＜0.05).Repeated measures ANOVA showed that total HAMD score and the score of cognitive impairment and sleep disturbance at the end of the 8th week were lower than those at the end of the 4th week(all P＜0.05).SCL-90 scores of the study group decreased at the end of the 4th and 8th week compared with those before treatment(all P＜0.05),while the SCL-90 scores of the study group were significantly lower than those in the control group(P＜0.05).There was no significant difference in TESS scores between the two groups after treatment(P＞0.05).Conclusion:Sertraline hydrochloride combined with rational emotion therapy can effectively improve depressive symptoms in adolescents,better than single drug treatment,and less adverse effects,worthy of clinical promotion and application.
NETL
NSTL
万方数据
