Expressions and clinical significances of serum miRNA-181c and miRNA-30e in patients with schizo-phrenia
Objective:To investigate the expressions of serum microRNA-181c(miRNA-181c)and mi-croRNA-30e(miR-30e)in patients with schizophrenia,and to analyze their relationships with cognitive function and prognosis.Method:138 schizophrenic patients admitted to our hospital from March 2019 to March 2021 were selected as the study group,and 123 healthy people in the same period were selected as the control group.The expressions of miR-181c and miR-30e in serum of them were detected by quantitative real time polymerase chain reaction(qRT-PCR).The cognitive function was assessed by the consensus version of MATRICS consen-sus cognitive battery(MCCB)and analyzed comparatively.The patients were followed up for 1 year.According to the prognosis,the patients were divided into the good prognosis group and the poor prognosis group.The rela-tionships between serum miR-181c and miR-30e expressions and poor prognosis of patients with schizophrenia were analyzed by multivariate Logistic regression analysis.Results:The expressions of miR-181c and miR-30e in the study group were higher than those in the control group(all P＜0.05),but the scores of all subtests and total score in MCCB evaluation were lower than those of the control group(all P＜0.05).Theexpressionsof ser-um miR-181c and miR-30e were negatively correlated with total score of MCCB(all P＜0.05).Follow up for 1 year of the study group,there were 80 cases(57.97%)with poor prognosis.The proportion of aggressive be-havior,the proportion of total score of MCCB＜50 and the expressions of serum miR-181c and miR-30e in the group with good prognosis were higher than those in the group with good prognosis(all P＜0.05).Theresults of multivariate Logistic regression analysis showed that aggressive behavior,total score of MCCB＜50 and serum miR-181c and miR-30e expressions were independent risk factors for poor prognosis of patients with schizophre-nia(all P＜0.05).Conclusion:The expressions of miR-181c and miR-30e in serum of patients with schizo-phrenia are significantly increased,and they are correlated with cognitive impairment,which are also risk factors for poor prognosis in patients with schizophrenia.
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