中国维吾尔族人群SLITRK1基因多态性与精神分裂症关联性研究
Association study of SLITRK1 gene polymorphism with schizophrenia in Uygur Chinese population
史新玉 1安治国 1孙乐乐 1罗晓 1闫萍 1杜雯 1靳路 1高帅帅 1伊琦忠1
作者信息
- 1. 830054 乌鲁木齐,新疆医科大学第一附属医院心理医学中心
- 折叠
摘要
目的:探讨SLITRK1 基因多态性与中国维吾尔族人群精神分裂症的关联性.方法:利用多重PCR靶向捕获二代测序技术对1008 例维吾尔族精神分裂症患者(病例组)及1095 例维吾尔族健康对照(对照组)进行SLITRK1 基因外显子区域DNA扩增,高通量测序,采用阳性与阴性症状量表(PANSS)对纳入研究患者进行临床精神病性症状的评定.结果:病例组与对照组间SLITRK1 基因rs145628951 位点等位基因和基因型频率分布差异无统计学意义(P均＞0.05);青少年发病病例组与对照组、成年发病病例组与对照组间rs145628951 位点等位基因和基因型频率分布差异均无统计学意义(P均＞0.05);男性病例组与对照组、女性病例组与对照组间rs145628951 位点等位基因和基因型频率分布差异均无统计学意义(P＞0.05);病例组中rs145628951 位点A/A、A/C、C/C基因型3 组间PANSS评分差异无统计学意义(P＞0.05).结论:SLITRK1 基因rs145628951 位点多态性与中国维吾尔族人群精神分裂症的发病无关联性.
Abstract
Objective:To explore the association between SLITRK1 gene polymorphism and schizophreni-a in the Uygur Chinese population.Method:SLITRK1gene exon region DNA amplification was performed with multiple PCR targeted capture next-generation sequencing method in 1008 patients with schizophrenia and 1095 healthy controls of Uyghur descent,and high-throughput sequencing was performed,the clinical psychiatric symptoms of schizophrenia were assessed by positive and negative syndrome scale(positive and negative symp-toms scale,PANSS).Results:There was no significant difference in the frequency distribution of alleles and genotypes at the rs145628951 of SLITRK1 gene between the case group and the control group(all P＞0.05);And genotypic or allelic of rs145628951 association with schizophrenia were not found between adolescent cases and controls or adult cases and controls(all P＞0.05);There was no significant difference in the distribution of allele and genotype frequencies of rs145628951 between male cases and controls,female cases and controls(P＞0.05);Furthermore,in the case group,there was no statistically significant difference in the scores of PANSS among the three genotypes of A/A,A/C,C/C in rs145628951(P＞0.05).Conclusion:There was no association between rs145628951 polymorphism of SLITRK1 gene and schizophrenia in Uygur Chinese.
关键词
精神分裂症/SLITRK1基因/维吾尔族/关联性研究Key words
schizophrenia/SLITRK1 gene/Uygur Chinese/association study引用本文复制引用
基金项目
国家自然科学基金(81360209)
国家自然科学基金(81660233)
国家自然科学基金(81960258)
出版年
2024
NETL
NSTL
万方数据