Effect of combined modified electroconvulsive therapy on plasma protein expression of CTNNA2 gene in schizophrenia and its therapeutic mechanism
Objective:To investigate the effect of modified electroconvulsive therapy(MECT)on the protein expression of CTNNA2 gene in patients with schizophrenia(SCZ)and the correlation between the ex-pression of CTNNA2 gene and clinical symptoms to explore the potential mechanism of MECT in the treatment of SCZ.Method:A total of 85 SCZ patients were enrolled,and 45 healthy controls(HC)were recruited.Before and 6 times after MECT,SCZ patients completed blood samples collection and were assessed with the Positive and Negative Syndrome Scale(PANSS)and the Brief Negative Symptom Scale(BNSS).Peripheral blood of HC group was collected during enrollment.The effect of MECT on plasma protein expression of CTNNA2 gene and the correlation between protein expression of CTNNA2 gene and clinical symptoms were analyzed.Results:Before MECT,plasma protein expression of CTNNA2 gene in SCZ group was higher than that in HC group,and the difference was statistically significant(t=9.063,P＜0.001).There was no statistically significant differ-ence in protein expression of CTNNA2 gene between the SCZ group and the HC group after MECT(t=0.811,P=0.419).The change of protein expression of CTNNA2 gene in the effective treatment group was negatively correlated with the reduction rate of general mental symptoms(r=-0.322,P＜0.01).Conclusion:MECT can reduce the protein expression of CTNNA2 gene in the plasma of SCZ patients and effectively relieve the clin-ical symptoms of SCZ patients,suggesting that MECT may play a role in treating SCZ by affecting the protein ex-pression of CTNNA2 gene.
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