精神分裂症阴性症状重复经颅磁刺激康复治疗效果研究
The effect of repetitive transcranial magnetic stimulation on the rehabilitation of negative symptoms in patients with schizophrenia
叶丹弟 1阎同军 2胡江燕 1陈孙克 1田海佳 1郑克 1李美花 1郑天生 1章洁 1陈兴时 3刘圆4
作者信息
- 1. 325000 温州医科大学附属康宁医院浙江省精神心理疾病临床医学研究中心
- 2. 联勤保障部队第 904 医院常州医疗区精神科
- 3. 上海市精神卫生中心神经生理室
- 4. 嘉兴市第一医院神经内科
- 折叠
摘要
目的:初步探讨重复经颅磁刺激(repeative transcranial magnetic stimulate,rTMS)对精神分裂症患者阴性症状的治疗效果以及对失匹负波(mismatch neagative,MMN)影响.方法:采用随机数字表法,对康复期精神分裂症患者96 例,随机分为3 组,分别给予5 Hz、10 Hz和15 Hz的rTMS治疗4 周(20次),分别于治疗前后测定并比较患者阴性症状量表(SANS)分值和MMN潜伏期和波幅.结果:与治疗前相比:①10 Hz组患者rTMS治疗后SANS量表分值明显下降(P＜0.05),而 5Hz和 15 Hz组SANS量表分值无明显改善;②在中央点(central zero,Cz),10 Hz组患者 rTMS治疗后 MMN波幅增高(P＜0.05),潜伏期无显著变化(P＞0.05),其余两组治疗前后 MMN潜伏期和波幅均未见明显变化.③10 Hz患者组SANS分值的改善状况与患者年龄及病程有关.结论:与 5Hz和 15 Hz的rTMS治疗相比,10 Hz的rTMS治疗可改善精神分裂症的阴性症状及认知功能,但这结果是初步的,还有待下一步临床转化中证实.
Abstract
Objective:To investigate the effects of rehabilitation therapy of repetitive transcranial mag-netic stimulation(rTMS)on the negative symptoms and on mismatch neagative(MMN)component of MMN in schizophrenia.Method:96 patients with age schizophrenia were randomly divided into 3 groups,treated by 5 Hz,10 Hz and 15 Hz rTMS for 4 weeks(20 times)respectively.The scores of Scale for Assessment of Nega-tive Symptoms(SANS)MMN latency and amplitude before and after were compared before and after the rTMS treatment.Results:①compared with the SANS score before treatment,the score of SANS decreased signifi-cantly after rTMS treatment in 10 Hz group(P＜0.05),which were not found in5 Hz and15 Hz rTMS group;②MMN amplitude in 10 Hz group was increased significantly after rTMS treatment(p＜0.05),while the MMN latency was not significantly changed(P＞0.05).③The improvement of SANS score in10 Hz group was relat-ed to the age and course of disease.Conclusion:Compared with 5 Hz and 15 Hz rTMS treatment,10 Hz rT-MS therapy can effectively improve the negative symptoms and cognitive function of schizophrenia.The mecha-nism needs further study.
关键词
精神分裂症/重复经颅磁刺激/阴性症状/失匹负波Key words
schizophrenia/repetitive transcranial magnetic stimulation/negative symptoms/mis-match neagative引用本文复制引用
出版年
2024
NETL
NSTL
万方数据