Efficacy of sodium valproate combined with lurasidone in the treatment of bipolar depressive episode and its effect on serum prolactin
Objective:To study the efficacy of sodium valproate combined with lurasidone in the treat-ment of depressive episode with bipolar disorder and its effect on serum prolactin(PRL).Method:100 pa-tients with bipolar depressive episode were divided into observation group and control group by random number table method,with 50 cases in each group.Two groups were respectively treated with lurasidone,sodium val-proate combined with lurasidone.The clinical efficacy,serological indexes[TSH,PRL,estradiol(E2)]levels,self-awareness and treatment attitude problems(ITAQ)scores,Positive and negative Emotion Scale(PANAS)scores,and incidence of adverse reactions were compared between the two groups.Results:The effective rates of the two groups were 95.65%and 81.40%,respectively,and the difference between the two groups was statis-tically significant(P＜0.05).After treatment,the positive emotion score of the observation group was higher than that of the control group,the negative emotion score was lower than that of the control group,and the differ-ence of PANAS score before and after treatment was higher in the observation group(P＜0.05).After treat-ment,PRL and E2 were increased in the two groups,and the observation group was higher than the control group,in addition,the difference of TSH,PRL and E2 levels before and after treatment was higher in the obser-vation group(P＜0.05).The ITAQ score of the two groups increased after treatment,and the ITAQ score of the observation group was higher than that of the control group,in addition,the difference of ITAQ score before and after treatment was higher in the observation group(P＜0.05).Conclusion:Sodium valproate combined with lurasidone in the treatment of bipolar depressive episode has good efficacy,can improve the emotional state of patients,increase serum PRL level,improve patients'cognitive ability,and high safety.
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