Study on rehabilitation effect of repetitive transcranial magnetic stimulation at different frequencies in patients with mild cognitive impairment
Objective:To observe the effect of repetitive transcranial magnetic stimulation(rTMS)with different frequencies on the mental and behavioral symptoms of elderly patients with mild cognitive impairment(MCI)and to evaluate the rehabilitation effect of event-related potential P300 and error-related negative poten-tial(ERN).Method:90 MCI patients with mental and behavioral symptoms were randomly divided into three groups by random number table method.rTMS at 5 Hz,10 Hz and 15 Hz were given for 6 weeks(30 times)respectively.The scores of mini-mental state examination(MMSE),P300 and ERN latency and am-plitude were measured and compared before and after treatment.Results:Compared with before treatment:①The MMSE score of patients in the 10 Hz group was significantly higher after rTMS treatment(P＜0.05),while the MMSE score of the 5 Hz and 15 Hz groups was not significantly improved;②After rTMS treatment,the am-plitude of P300 and ERN in 10Hz group increased(both P＜0.05).There was no significant change in the la-tency(P＞0.05),and there was no significant change in the latency and amplitude of P300 and ERN in the other two groups before and after treatment.③ The improvement of MMSE score in the 10 Hz patient group is related to the age and course of disease of the patient.Conclusion:rTMS with high frequency of 10Hz can significantly relieve the mental and behavioral symptoms of MCI patients and improve the cognitive function of patients.This therapy is worthy of further clinical promotion.P300 and ERN can be used for follow-up evaluation.
mild cognitive impairmentrepeated transcranial magnetic stimulationP300error related negative potentialrehabilitation assessment
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