谷氨酸脱羧酶1在精神疾病中的研究进展
Advances in the study of glutamic acid decarboxylase 1 in psychiatric disorders
吴慧琴 1王纯1
作者信息
- 1. 210009 南京医科大学附属南京脑科医院
- 折叠
摘要
谷氨酸脱羧酶(glutamic acid decarboxylase,GAD)是 γ-氨基丁酸(γ-aminobutyric acid,GA-BA)的合成酶,主要在脑和胰岛中存在.GABA的异常表达与多种疾病相关,多项研究表明其合成酶GAD1 可能参与精神疾病的发病过程,现就GAD1 研究的新进展及其可能的致病机制进行综述.
Abstract
Glutamic acid decarboxylase(GAD)is a synthetic enzyme of γ-aminobutyric acid(GABA),which is mainly found in the brain and pancreatic islets,and its aberrant expression has been associated with a variety of diseases,and several studies have shown that its synthetic enzyme,GAD1,may be involved in the pathogenesis of psychiatric disorders.The new developments in the study of GAD1 and its possible pathogenic mechanisms are summarized here.
关键词
谷氨酸脱羧酶1/精神疾病/致病机制/基因多态性Key words
glutamic acid decarboxylase 1/mental illness/pathogenesis/gene polymorphisms引用本文复制引用
基金项目
国家自然科学基金(81971289)
江苏省重点研发计划(BE2019609)
江苏省六个一拔尖人才项目(LGY2019007)
出版年
2024
NETL
NSTL
万方数据