首页|谷氨酸脱羧酶1在精神疾病中的研究进展

谷氨酸脱羧酶1在精神疾病中的研究进展

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谷氨酸脱羧酶(glutamic acid decarboxylase,GAD)是 γ-氨基丁酸(γ-aminobutyric acid,GA-BA)的合成酶,主要在脑和胰岛中存在.GABA的异常表达与多种疾病相关,多项研究表明其合成酶GAD1 可能参与精神疾病的发病过程,现就GAD1 研究的新进展及其可能的致病机制进行综述.
Advances in the study of glutamic acid decarboxylase 1 in psychiatric disorders
Glutamic acid decarboxylase(GAD)is a synthetic enzyme of γ-aminobutyric acid(GABA),which is mainly found in the brain and pancreatic islets,and its aberrant expression has been associated with a variety of diseases,and several studies have shown that its synthetic enzyme,GAD1,may be involved in the pathogenesis of psychiatric disorders.The new developments in the study of GAD1 and its possible pathogenic mechanisms are summarized here.

glutamic acid decarboxylase 1mental illnesspathogenesisgene polymorphisms

吴慧琴、王纯

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210009 南京医科大学附属南京脑科医院

谷氨酸脱羧酶1 精神疾病 致病机制 基因多态性

国家自然科学基金江苏省重点研发计划江苏省六个一拔尖人才项目

81971289BE2019609LGY2019007

2024

临床精神医学杂志
南京医科大学附属脑科医院

临床精神医学杂志

CSTPCD
影响因子:1.108
ISSN:1005-3220
年,卷(期):2024.34(3)