The association between pregnancy and prenatal weight with offspring autism spectrum disorders
Objective:To explore the relationship between pre-pregnancy body mass index(BMI),gestational weightgain and offspring autism spectrum disorder(ASD).Method:221 children with ASD for outpatient department from January 2023 to June 2023 were enrolled as the ASD group,and 137 children with typical development matched in age and sex were recruited in the community.Using a self-designed general situation questionnaire,filled out by parents of enrolled children to collect detailed clinical data of the study subjects during the perinatal period;SPSS 26.0 statistical software was used and the data were analyzed by chi-square test,and multinomial logistics regression.Results:The detection rate of low body weight before pregnancy was 18.7％(67 cases),with an average weight gain of(14.41±5.88)kg during pregnancy.The detection rate of insufficient weight gain during pregnancy was 9.8％(35 cases),and the detection rate of excessive weight gain during pregnancy was 44.9％(161 cases).There was statistical difference between male and female children(x2=25.6,P=0.000).There is a difference in the incidence of autism between the overweight group,the appropriate weight gain group,and the underweight group during pregnancy(all P＜0.05).Conclusion:Excessive weight gain during pregnancy is a risk factor for ASD in offspring.
autism spectrum disorderpregnancy weight gainpre-pregnancy body mass index
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NSTL
万方数据
