The efficacy and safety of blue-blocking intervention on biological rhythms in bipolar patients during maintenance treatment
Objective:To explore the efficacy and safety of blue-blocking intervention on biological rhythm and sleep in bipolar disorder patients with insomnia during maintenance treatment.Method:45 eligible patients with bipolar disorder from September 2020 to April 2023,at Shanghai Hongkou Mental Health Center were randomly divided into an intervention group(22 cases)and a control group(23 cases).On the basis of maintaining the original treatment,patients in the intervention group wore orange glasses of blocking blue light for at least 2 hours every night during 4 weeks,while patients in the control group did not receive any additional intervention.At baseline,second week and fourth week,patients in both two groups were assessed with the Chinese version of biological rhythms interview of assessment in neuropsychiatry(BRIAN-C)and Pittsburgh sleep quality index(PSQI).Results:Compared between the two groups,repeated measurement analysis of variance showed that BRIAN-C score(F-time=17.257,P=0.000)and PSQI score(F-time=17.144,P=0.000)had a significant time effect(all P＜0.01).At the end of the 4th week,there was also a statistically significant difference in the dominant rhythm factor scores of BRIAN-C between the two groups(Z=-2.266,P＜0.05).Neither group reported any adverse events related to the study.Conclusion:Blue-blocking as additive treatment is effective in improving biological rhythm disruption and insomnia symptoms in patients with bipolar disorder during maintenance therapy,and has good safety and tolerance.
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