目的:分析首发未治疗精神分裂症住院患者并发高尿酸血症的相关因素.方法:纳入2021年1月至2022年12月在首都医科大学附属北京安定医院住院的首发未治疗的精神分裂患者,根据尿酸结果分为无高尿酸血症组(n=127)和有高尿酸血症组(n=73),对两组患者的一般人口学资料及相关指标进行比较,采用二项Logistic回归分析首发未治疗精神分裂症住院患者并发高尿酸血症的相关因素.结果:与无高尿酸血症患者组相比较,有高尿酸血症患者组的年龄及发病年龄小、精神疾病家族史阳性者比例高、吸烟者比例高、白蛋白低、三酰甘油高、高密度脂蛋白低、体质量指数(body mass index,BMI)高、有高血压及高血脂的比例高(P均＜0.05).分析结果显示,BMI高、阳性症状评分高均是首发未治疗精神分裂症住院患者患高尿酸血症的危险因素(OR均＞1.00,P均＜0.05);年龄小、不吸烟、未患有高血压及高血脂均是首发未治疗精神分裂症住院患者患高尿酸血症的保护因素(OR均＜1.00,P均＜0.05).结论:首发未治疗精神分裂症患者的尿酸水平与精神症状相关,阳性症状、BMI指数、年龄、吸烟、高血压、高血脂是其患高尿酸血症的独立危险因素.
Analysis of factors associated with concurrent hyperuricemia in patients hospitalized with first-episode drug-free schizophrenia
Objective:An analysis of factors associated with comorbid hyperuricemia in patients hospitalized with first-episode drug-free schizophrenia.Method:The study population consisted of first-episode untreated schizophrenic patients admitted to Beijing An Ding Hospital,Capital Medical University,from January 2021 to December 2022.Relevant data were collected and divided into the group without hyperuricemia(n=127)and the group with hyperuricemia(n=73)according to uric acid results.The general demographic data and relevant indexes of the two groups were compared.The factors associated with concomitant hyperuricemia in patients with first untreated schizophrenia hospitalization were analyzed by binomial logistic regression.Results:Compared with the group without hyperuricemia,the group with hyperuricemia had a lower age and onset age,a higher proportion of people with a positive family history of mental illness,a higher proportion of smokers,lower albumin,higher triglycerides,lower high-density lipoprotein,higher body mass index(BMI),and a higher proportion of people with hypertension and hyperlipidemia(all P＜0.05).The results of binomial logistic regression analysis showed that high BMI and positive symptom scores were risk factors for hyperuricemia in hospitalized patients with untreated first-episode schizophrenia(all OR＞1.00,all P＜0.05);Young age,non-smoking,absence of hypertension and hyperlipidemia were protective factors for hyperuricemia in hospitalized patients with untreated schizophrenia for the first time(all OR＜1.00,all P＜0.05).Conclusion:The uric acid level in untreated first-episode schizophrenics is associated with psychiatric symptoms.Positive symptoms,BMI,age,smoking,hypertension,and hyperlipidemia are independent risk factors for hyperuricemia.
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