替换或加用齐拉西酮对精神分裂症患者代谢综合征的影响
Effect of replacement or addition of ziprasidone on metabolic indices in schizophrenia patients with metabolic syndrome
欧阳紫颖 1杨远坚 1李逸恒 1魏波1
作者信息
- 1. 330029 江西省精神病院,江西省精神心理疾病临床研究中心
- 折叠
摘要
目的:探讨换用或加用齐拉西酮对精神分裂症(schizophrenia,SCZ)患者代谢综合征(metabolic syndrome,MetS)的影响.方法:纳入2022年7月至2022年12月在江西省精神病院的60例伴有MetS的精神分裂症患者,分为换用齐拉西酮组(n=30)和联用齐拉西酮组(n=30).收集患者的基本情况,并对其换药前以及换药后4周和8周的各项代谢指标进行检测和比较.结果:有48例患者完成研究,换用齐拉西酮组(n=28)的腰围(F=5.635,P=0.0165),三酰甘油(F=7.944,P=0.0069),收缩压(F=6.227,P=0.0107)和舒张压(F=4.960,P=0.0210)明显降低,高密度脂蛋白明显升高(F=3.406,P=0.0405).联用齐拉西酮组(n=20)的腰围(F=21.58,P＜0.0001)和收缩压(F=4.396,P=0.0318)明显降低.这些代谢指标在换用组和联用组之间以及不同剂量齐拉西酮之间差异均无统计学意义.结论:换用或联用齐拉西酮可作为临床处理SCZ患者出现MetS不良反应的一种可行方案.
Abstract
Objective:To investigate the effect of switching to ziprasidone or adding ziprasidone on metabolic syndrome(MetS)in patients with schizophrenia(SCZ).Method:A total of 60 SCZ patients with MetS in Jiangxi Mental Hospital from July 2022 to December 2022 were enrolled and divided into two groups,one group was switched to ziprasidone(n=30),and the other group was combined with ziprasidone(n=30).Basic information of patients was collected and metabolic indexes were measured and compared before and after 4 or 8 weeks switching to ziprasidone.Results:A total of 48 patients completed the study.Metabolic parameters of patients who were switched to ziprasidone(n=28)were significantly improved,including lower waist circumference(F=5.635,P=0.0165),triglyceride(F=7.944,P=0.0069),systolic blood pressure(F=6.227,P=0.0107),diastolic blood pressure(F=4.960,P＜0.05)and higher high-density lipoprotein(F=3.406,P=0.0405).Waist circumference(F=21.58,P＜0.0001)and systolic blood pressure(F=4.396,P=0.0318)were significantly decreased in the group combined with ziprasidone(n=20)(P＞0.05).There were no significant differences in these metabolic indexes between two groups,nor among different doses of ziprasidone.Conclusion:Switching to or combined with ziprasidone can be used as a feasible scheme for the treatment of MetS in patients with SCZ.
关键词
精神分裂症/代谢综合征/齐拉西酮Key words
schizophrenia/metabolic syndrome/ziprasidone引用本文复制引用
基金项目
江西省科技计划项目(2020BCG74002)
出版年
2024
NETL
NSTL
万方数据