Effect of replacement or addition of ziprasidone on metabolic indices in schizophrenia patients with metabolic syndrome
Objective:To investigate the effect of switching to ziprasidone or adding ziprasidone on metabolic syndrome(MetS)in patients with schizophrenia(SCZ).Method:A total of 60 SCZ patients with MetS in Jiangxi Mental Hospital from July 2022 to December 2022 were enrolled and divided into two groups,one group was switched to ziprasidone(n=30),and the other group was combined with ziprasidone(n=30).Basic information of patients was collected and metabolic indexes were measured and compared before and after 4 or 8 weeks switching to ziprasidone.Results:A total of 48 patients completed the study.Metabolic parameters of patients who were switched to ziprasidone(n=28)were significantly improved,including lower waist circumference(F=5.635,P=0.0165),triglyceride(F=7.944,P=0.0069),systolic blood pressure(F=6.227,P=0.0107),diastolic blood pressure(F=4.960,P＜0.05)and higher high-density lipoprotein(F=3.406,P=0.0405).Waist circumference(F=21.58,P＜0.0001)and systolic blood pressure(F=4.396,P=0.0318)were significantly decreased in the group combined with ziprasidone(n=20)(P＞0.05).There were no significant differences in these metabolic indexes between two groups,nor among different doses of ziprasidone.Conclusion:Switching to or combined with ziprasidone can be used as a feasible scheme for the treatment of MetS in patients with SCZ.
NETL
NSTL
万方数据
