摘要
目的:采用两样本孟德尔随机化方法分析甲亢/甲减与9种精神疾病发生风险的因果关联.方法:甲亢/甲减与九种精神疾病研究数据来自公开发表的数据.从汇总数据中筛选出高度相关的单核苷酸多态性位点作为工具变量,主分析利用逆方差加权法,并应用MR-Egger回归、最大似然法等评估甲亢/甲减与九种精神疾病之间的因果效应,后进行异质性和多效性检验.结果:遗传预测的甲亢与焦虑障碍、抑郁、躯体形式障碍、睡眠障碍、精神分裂症、双相情感障碍、躁狂发作、注意力缺陷多动障碍、孤独症谱系障碍之间没有因果关系(OR=1.000、0.998、0.928、1.042、1.011、0.945、0.997、1.028、0.999);甲减与同上九种精神疾病之间亦没有因果关系(OR=0.999、1.005、1.407、1.305、0.654、0.864、1.025、1.107、0.908).结论:暂未有充分的证据支持甲亢/甲减与九种精神疾病风险之间存在因果关联.
Abstract
Objective:To analyze the causal association between hyperthyroidism/hypothyroidism and the risk of developing nine psychiatric disorders using a two-sample Mendelian randomization study.Method:Data on hyperthyroidism/hypothyroidism and nine psychiatric disorders were obtained from publicly available data.Highly correlated single nucleotide polymorphism loci were screened as instrumental variables from the pooled data,and the main analyses utilized the inverse variance weighting method,and MR-Egger regression and maximum likelihood method were also applied to assess the causal effects between hyperthyroidism/hypothyroidism and the nine psychiatric disorders,and to test for heterogeneity and multiple validity.Results:There was no causal relationship between genetically predicted hyperthyroidism(OR=1.000,0.998,0.928,1.042,1.011,0.945,0.997,1.028,0.999)/hypothyroidism(OR=0.999,1.005,1.407,1.305,0.654,0.864,1.025,1.107,0.908)and the nine psychiatric disorders.Conclusion:There is insufficient evidence to support a causal association between hyperthyroidism/hypothyroidism and the risk of the nine psychiatric disorders for the time being.
NETL
NSTL
万方数据