Exploring the causal relationship between thyroid dysfunction and 9 psychiatric disorders:a mendelian randomization study
Objective:To analyze the causal association between hyperthyroidism/hypothyroidism and the risk of developing nine psychiatric disorders using a two-sample Mendelian randomization study.Method:Data on hyperthyroidism/hypothyroidism and nine psychiatric disorders were obtained from publicly available data.Highly correlated single nucleotide polymorphism loci were screened as instrumental variables from the pooled data,and the main analyses utilized the inverse variance weighting method,and MR-Egger regression and maximum likelihood method were also applied to assess the causal effects between hyperthyroidism/hypothyroidism and the nine psychiatric disorders,and to test for heterogeneity and multiple validity.Results:There was no causal relationship between genetically predicted hyperthyroidism(OR=1.000,0.998,0.928,1.042,1.011,0.945,0.997,1.028,0.999)/hypothyroidism(OR=0.999,1.005,1.407,1.305,0.654,0.864,1.025,1.107,0.908)and the nine psychiatric disorders.Conclusion:There is insufficient evidence to support a causal association between hyperthyroidism/hypothyroidism and the risk of the nine psychiatric disorders for the time being.
NETL
NSTL
万方数据
