外周血中性粒细胞/淋巴细胞比率和单核细胞/淋巴细胞比率在精神分裂症患者中的应用探讨
Application of peripheral blood neutrophil-lymphocyte ratio and monocyte-lymphocyte ratio in schizophrenia
方欢英 1江峰 1刘遵建 1贺辰冏1
作者信息
- 1. 200090 上海市杨浦区精神卫生中心检验科,上海健康医学院精神卫生临床研究中心
- 折叠
摘要
目的:探讨精神分裂症患者血细胞分析衍生参数中性粒细胞/淋巴细胞比率(neutrophil/lymphocyte ratio,NLR)和单核细胞/淋巴细胞比率(monocyte/lymphocyte ratio,MLR)水平的变化.方法:纳入2021年6月至2022年3月在上海市杨浦区精神卫生中心就诊入院的139例精神分裂症患者(分为攻击组56例和非攻击组83例)和95名健康对照者,分析其血细胞计数及MLR、NLR结果,并评估其与年龄和性别的相关性.结果:与健康对照组相比,中性粒细胞计数[4.04(3.18,5.16)VS 3.48(2.72,4.25)]、NLR[2.312(1.596,3.104)VS 1.772(1.351,2.284)]和 MLR[0.253(0.206,0.319)VS 0.222(0.192,0.270)]均显著升高,差异有统计学意义(P均＜0.05).与非攻击组相比,攻击组中性粒细胞计数[4.53(3.65,5.73)VS 3.48(2.73,5.02)]、NLR[2.960(2.215,3.794)VS 1.772(1.350,2.613)]和 MLR[0.294(0.231,0.365)VS 0.227(0.184,0.285)]均显著升高,差异有统计学意义(P 均＜0.001).此外,NLR、MLR与年龄、性别之间的相关性均无统计学意义(P均＞0.05).结论:NLR、MLR在精神分类症患者中显著升高,支持精神分裂症炎症假说,或可作为预测攻击行为发生的血液标志物,具有一定的临床应用价值.
Abstract
Objective:To explore the changes in neutrophil/lymphocyte ratio(NLR)and monocyte/lymphocyte ratio(MLR)in patients with schizophrenia.Method:139 schizophrenic patients were divided into the attack group(n=56)and the non-attack group(n=83),and 95 healthy controls who were admitted to Shanghai Yangpu District Mental Health Center from June 2021 to March 2022 were included.Total blood cell counts,NLR and MLR results were analyzed and compared,and their correlations with age and sex were evaluated.Results:The neutrophil count[4.04(3.18,5.16)VS 3.48(2.72,4.25)],NLR[2.312(1.596,3.104)VS 1.772(1.351,2.284)]and MLR[0.253(0.206,0.319)VS 0.222(0.192,0.270)]were significantly higher in patients with schizophrenia compared to healthy controls(all P＜0.05).Compared with the non-aggressive group,the neutrophil count[4.53(3.65,5.73)VS 3.48(2.73,5.02)],NLR[2.960(2.215,3.794)VS 1.772(1.350,2.613)],and MLR[0.294(0.231,3.365)VS 0.227(0.184,0.285)]in the aggressive group were significantly increased,with statistically significant differences(all P＜0.001).In addition,there was no significant correlation between NLR,MLR,age,and gender(all P＞0.05).Conclusion:NLR and MLR are significantly elevated in patients with schizophrenia,supporting the inflammatory hypothesis of schizophrenia and perhaps serving as blood markers for predicting aggressive behavior,which has certain clinical application value.
关键词
精神分裂症/中性粒细胞/淋巴细胞比率/单核细胞/淋巴细胞比率/攻击行为Key words
schizophrenia/neutrophil/lymphocyte ratio/monocyte/lymphocyte ratio/aggressive behavior引用本文复制引用
基金项目
上海健康医学院精神卫生临床研究中心项目(20MC2020005)
上海市杨浦区科学技术委员会和卫生健康委员会科研项目(YPM202316)
出版年
2024
NETL
NSTL
万方数据