Application of peripheral blood neutrophil-lymphocyte ratio and monocyte-lymphocyte ratio in schizophrenia
Objective:To explore the changes in neutrophil/lymphocyte ratio(NLR)and monocyte/lymphocyte ratio(MLR)in patients with schizophrenia.Method:139 schizophrenic patients were divided into the attack group(n=56)and the non-attack group(n=83),and 95 healthy controls who were admitted to Shanghai Yangpu District Mental Health Center from June 2021 to March 2022 were included.Total blood cell counts,NLR and MLR results were analyzed and compared,and their correlations with age and sex were evaluated.Results:The neutrophil count[4.04(3.18,5.16)VS 3.48(2.72,4.25)],NLR[2.312(1.596,3.104)VS 1.772(1.351,2.284)]and MLR[0.253(0.206,0.319)VS 0.222(0.192,0.270)]were significantly higher in patients with schizophrenia compared to healthy controls(all P＜0.05).Compared with the non-aggressive group,the neutrophil count[4.53(3.65,5.73)VS 3.48(2.73,5.02)],NLR[2.960(2.215,3.794)VS 1.772(1.350,2.613)],and MLR[0.294(0.231,3.365)VS 0.227(0.184,0.285)]in the aggressive group were significantly increased,with statistically significant differences(all P＜0.001).In addition,there was no significant correlation between NLR,MLR,age,and gender(all P＞0.05).Conclusion:NLR and MLR are significantly elevated in patients with schizophrenia,supporting the inflammatory hypothesis of schizophrenia and perhaps serving as blood markers for predicting aggressive behavior,which has certain clinical application value.
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