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布南色林临床应用进展

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第二代(非典型)抗精神病药布南色林对多巴胺D2、D3受体和5-羟色胺2A(5 Hydroxytryptamine 2A receptor,5-HT2A)受体均有较高亲和力,而对肾上腺素α1、5-HT2C、组胺H1、毒蕈碱M1和M3等受体亲和力较低.近10年临床研究显示布南色林不仅对精神分裂症的阳性症状、阴性症状均有较好疗效,同时还具有抗焦虑抗抑郁作用,对患者的认知及其社会功能的改善疗效优越.
Advances in clinical application of blonanserin
The second-generation(atypical)antipsychotic of Blonanserin has high affinity for dopamine D2,D3 and 5 Hydroxytryptamine 2A receptor(5-HT2 A)receptors and lower affinity for adrenergic α1,5-HT2C,histamine H1,muscarinic M1 and muscarinic M3.More than a decade of clinical research has shown that:Blonanserin not only has a good effect on positive and negative symptoms of schizophrenia,but also has an anti-anxiety and anti-depression effect,and has a good effect on patients'cognition and social function.

blonanserinschizophreniaclinical application

陈燕、王帅

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244000 铜陵市第三人民医院

布南色林 精神分裂症 临床应用

2024

临床精神医学杂志
南京医科大学附属脑科医院

临床精神医学杂志

CSTPCD
影响因子:1.108
ISSN:1005-3220
年,卷(期):2024.34(4)