Effectiveness of the θ short array fast pulse repetitive transcranial magnetic stimulation model for the treatment of depression based on neurobiological mechanisms
Objective:To explore the therapeutic effect of repetitive transcranial magnetic stimulation-theta burst stimulation(rTMS-TBS)mode on depression.Method:Ninety-two patients with depression were divided into the TBS group,the conventional mode group and the pseudo-stimulation group by random number table method,all were given conventional medication and rTMS-TBS mode stimulation,rTMS conventional mode stimulation and pseudo-stimulation intervention respectively.The treatment effects,adverse effects,Hamilton depression scale(HAMD),Hamilton anxiety scale(HAMA),neurotransmitter power[dopamine(DA),gamma aminobutyric acid(GABA)],and vegetative function[sympathetic skin response(SSR)amplitude and latency]of the three groups were counted and compared before and after treatment.Results:The total effective rate of treatment was 87.10％in the TBS group,which was higer than 61.29％in the conventional mode group and 40.00％in the pseudo-stimulation group(P＜0.05);at week 2 and 4 of treatment,SSR latency,HAMD and HAMA in the TBS group＜conventional mode group＜pseudo-stimulation group,DA,GABA and SSR wave amplitude＞conventional mode group＞pseudo-stimulation group(P＜0.05);the difference was not statistically significant when comparing the adverse effects of the three groups(P＞0.05).Conclusion:The effect of rTMS-TBS stimulation in the treatment of depression patients is better than that of conventional mode,which can effectively improve the symptoms of anxiety and depression,relieve sleep disorders,improve the autonomic nerve function,and has high safety.
repetitive transcranial magnetic stimulationdepressionθ-burst stimulationnervesleep
万方数据
维普
