Correlation analysis of neural cell adhesion molecules,cone-like protein-1 expression and cognitive dysfunction in schizophrenia
Objective:To analyze of the correlation of nerve cell adhesion molecules(NCAM),cone-like protein-1(VILIP-1)expression and cognitive dysfunction in schizophrenia.Method:Sixty-five patients treated for schizophrenia in our hospital were selected as the disease group,and 60 patients treated for health examination in our hospital were selected as the health group.Their interleukin-1 β(IL-1 β),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),NCAM and VILIP-1 were detected;schizophrenia severity and cognitive function were evaluated by positive and negative syndrome scale(PANSS)and Montreal cognitive assessment(MoCA)score.Results:Compared to the healthy group,NCAM expression level was lower in the disease group,expression level of VILIP-1 was higher(all P＜0.05);There was a negative correlation between NCAM and PANSS scores,and a positive correlation between NCAM and MoCA score(all P＜0.05);there was a positive correlation between VILIP-1 and PANSS scores,and a negative correlation between VILIP-1 and MoCA score(all P＜0.05);the receiver operation characteristic(ROC)curve analysis revealed that,compared with the single diagnosis of NCAM and VILIP-1,the combined test had a higher value in the diagnosis of schizophrenia(all P＜0.05).Conclusion:The abnormal increased or decreased expression in NCAM and VILIP-1 expression level is a risk predictor of schizophrenia,which may be closely related to the diagnosis,development and cognitive function of the disease.
万方数据
维普
