Objective:This study aimed to validate the diagnostic efficiency of near-infrared spectroscopy(NIRS)for depressive disorders.Method:A total of subjects aged 18 to 60 years,from September 2020 to May 2022,in ZhongDa Hospital,Southeast University were enrolled,including 197 patients with depressive disorder and 138 gender and age matched healthy controls.Multi-channel NIRS was used to detect the changes of oxy-haemoglobin concentration over time in all subjects during the verbal fluency task.The sensitivity and specificity of NIRS spectroscopy in the objective diagnosis of depressive disorder were calculated.Receiver operator characteristic was used to analyze the diagnostic efficiency of NIRS indexes including K-activation value,S integral score,peak oxy-haemoglobin value and T centroid value for common mental disorders.Results:The diagnostic sensitivity and specificity of NIRS were 92％and 78％for depressive disorder.Receiver operator characteristic analyses showed that S integral score and peak oxy-haemoglobin is of great value in diagnosing depressive disorder.However,none of the NIRS indexes could manifest the depressive severity.Conclusion:NIRS spectrum was of great value for objectively diagnosing depressive disorder.
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